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Found 1380 with Last Name = 'yao' and Initial = 'x'
LigandPNGBDBM50036910(4-(1-Naphthalen-1-yl-ethyl)-1H-imidazole | CHEMBL3...)
Affinity DataKi:  13nMAssay Description:Alpha-2 adrenergic receptor binding affinity was tested against membrane preparations of rat brain using 0.2 nM [3H]rauwolscine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50036913((+-)-4-(alpha,2,3-trimethylbenzyl)imidazole | 4-[1...)
Affinity DataKi:  25nMAssay Description:Alpha-2 adrenergic receptor binding affinity was tested against membrane preparations of rat brain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50470860(CHEMBL105328)
Affinity DataKi:  33nMAssay Description:Alpha-2 adrenergic receptor binding affinity was tested against membrane preparations of rat brain using 0.2 nM [3H]rauwolscine as radioligandMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Ohio State University

Curated by ChEMBL
LigandPNGBDBM50470860(CHEMBL105328)
Affinity DataKi:  55nMAssay Description:Alpha-1 adrenergic receptor binding affinity in rat brain membranesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Ohio State University

Curated by ChEMBL
LigandPNGBDBM50470861(CHEMBL322844)
Affinity DataKi:  57nMAssay Description:Alpha-1 adrenergic receptor binding affinity in rat brain membranesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50470859(CHEMBL105487)
Affinity DataKi:  122nMAssay Description:Alpha-2 adrenergic receptor binding affinity was tested against membrane preparations of rat brain using 0.2 nM [3H]rauwolscine as radioligandMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50470862(CHEMBL102076)
Affinity DataKi:  165nMAssay Description:Alpha-2 adrenergic receptor binding affinity was tested against membrane preparations of rat brain using 0.2 nM [3H]rauwolscine as radioligandMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50223426(CHEBI:10304 | Corbadrine | Levonordefrin | Neo-Cob...)
Affinity DataKi:  205nMAssay Description:Alpha-2 adrenergic receptor binding affinity was tested against membrane preparations of rat brain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Ohio State University

Curated by ChEMBL
LigandPNGBDBM50036910(4-(1-Naphthalen-1-yl-ethyl)-1H-imidazole | CHEMBL3...)
Affinity DataKi:  224nMAssay Description:Alpha-1 adrenergic receptor binding affinity in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Ohio State University

Curated by ChEMBL
LigandPNGBDBM50470863(CHEMBL102669)
Affinity DataKi:  387nMAssay Description:Alpha-1 adrenergic receptor binding affinity in rat brain membranesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Ohio State University

Curated by ChEMBL
LigandPNGBDBM50470862(CHEMBL102076)
Affinity DataKi:  574nMAssay Description:Alpha-1 adrenergic receptor binding affinity in rat brain membranesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Ohio State University

Curated by ChEMBL
LigandPNGBDBM50470864(CHEMBL420652)
Affinity DataKi:  655nMAssay Description:Alpha-1 adrenergic receptor binding affinity in rat brain membranesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Ohio State University

Curated by ChEMBL
LigandPNGBDBM50036913((+-)-4-(alpha,2,3-trimethylbenzyl)imidazole | 4-[1...)
Affinity DataKi:  1.11E+3nMAssay Description:Alpha-1 adrenergic receptor binding affinity in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50470864(CHEMBL420652)
Affinity DataKi:  1.45E+3nMAssay Description:Alpha-2 adrenergic receptor binding affinity was tested against membrane preparations of rat brain.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50470863(CHEMBL102669)
Affinity DataKi:  1.47E+3nMAssay Description:Alpha-2 adrenergic receptor binding affinity was tested against membrane preparations of rat brain using 0.2 nM [3H]rauwolscine as radioligandMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Ohio State University

Curated by ChEMBL
LigandPNGBDBM50470859(CHEMBL105487)
Affinity DataKi:  1.73E+3nMAssay Description:Alpha-1 adrenergic receptor binding affinity in rat brain membranesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50470861(CHEMBL322844)
Affinity DataKi:  1.89E+3nMAssay Description:Alpha-2 adrenergic receptor binding affinity was tested against membrane preparations of rat brain using 0.2 nM [3H]rauwolscine as radioligandMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Ohio State University

Curated by ChEMBL
LigandPNGBDBM50223426(CHEBI:10304 | Corbadrine | Levonordefrin | Neo-Cob...)
Affinity DataKi:  9.22E+3nMAssay Description:Alpha-1 adrenergic receptor binding affinity in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50326469(3,4'-Dihydroxy-3',5'-dimethoxybiphenyl-4-carboxyli...)
Affinity DataKi:  1.50E+4nMAssay Description:Competitive inhibition of mushroom tyrosinase after 30 mins by Lineweaver-Burk double reciprocal plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50326455(CHEMBL1243344 | N-Butyl-4'-hydroxy-3',5'-dimethoxy...)
Affinity DataKi:  3.10E+4nMAssay Description:Competitive inhibition of mushroom tyrosinase after 30 mins by Lineweaver-Burk double reciprocal plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50326456(4'-Hydroxy-3',5'-dimethoxybiphenyl-4-carboxylic ac...)
Affinity DataKi:  3.80E+4nMAssay Description:Competitive inhibition of mushroom tyrosinase after 30 mins by Lineweaver-Burk double reciprocal plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50326467(CHEMBL1243315 | N-Benzyl-3,4'-dihydroxy-3',5'-dime...)
Affinity DataKi:  6.00E+4nMAssay Description:Competitive inhibition of mushroom tyrosinase after 30 mins by Lineweaver-Burk double reciprocal plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50376040(CHEMBL272824)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of human VEGFR2 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIleal sodium/bile acid cotransporter(Rattus norvegicus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50434850(CHEMBL2387397)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of rat ASBT expressed in HEK293 cells assessed as inhibition of [3H]-taurocholate uptake after 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50375681(CHEMBL411630)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of human VEGFR2 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50376025(AMG-0309 | CHEMBL409538)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of human VEGFR2 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50416746(CHEMBL1242387)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of human VEGFR2 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIleal sodium/bile acid cotransporter(Mus musculus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50434850(CHEMBL2387397)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of mouse ASBT expressed in HEK293 cells assessed as inhibition of [3H]-taurocholate uptake after 90 mins by scintillation counting analysi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50376036(CHEMBL270092)
Affinity DataIC50:  0.302nMAssay Description:Inhibition of human VEGFR2 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50376026(CHEMBL272691)
Affinity DataIC50:  0.302nMAssay Description:Inhibition of human VEGFR2 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50376019(CHEMBL429585)
Affinity DataIC50:  0.302nMAssay Description:Inhibition of human VEGFR2 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50376030(CHEMBL269916)
Affinity DataIC50:  0.302nMAssay Description:Inhibition of human VEGFR2 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50416748(CHEMBL1241686)
Affinity DataIC50:  0.372nMAssay Description:Inhibition of human VEGFR2 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50375999(CHEMBL270342)
Affinity DataIC50:  0.447nMAssay Description:Inhibition of human VEGFR2 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50236362(CHEMBL429743 | N-(4-chlorophenyl)-6-(6,7-dimethoxy...)
Affinity DataIC50:  0.490nMAssay Description:Inhibition of human VEGFR2 after 60 minsMore data for this Ligand-Target Pair
TargetIleal sodium/bile acid cotransporter(Mus musculus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50434849(CHEMBL2385105 | US9040518, 6)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of mouse ASBT expressed in HEK293 cells assessed as inhibition of [3H]-taurocholate uptake after 90 mins by scintillation counting analysi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50375679(CHEMBL270548)
Affinity DataIC50:  0.501nMAssay Description:Inhibition of human VEGFR2 after 60 minsMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50416745(CHEMBL1242575)
Affinity DataIC50:  0.501nMAssay Description:Inhibition of human VEGFR2 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50376035(AMG-6168 | CHEMBL411091)
Affinity DataIC50:  0.501nMAssay Description:Inhibition of human VEGFR2 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50376034(CHEMBL271563)
Affinity DataIC50:  0.501nMAssay Description:Inhibition of human VEGFR2 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50376033(CHEMBL270985)
Affinity DataIC50:  0.501nMAssay Description:Inhibition of human VEGFR2 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Mus musculus (Mouse))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154612(US8999957, Column 165-167, Compound 1)
Affinity DataIC50:  0.600nMAssay Description:Condition 2: Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each comp...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50236856(CHEMBL272198 | N-cyclopropyl-6-(6,7-dimethoxyquino...)
Affinity DataIC50:  0.603nMAssay Description:Inhibition of human VEGFR2 after 60 minsMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50376038(CHEMBL412291)
Affinity DataIC50:  0.603nMAssay Description:Inhibition of human VEGFR2 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50416744(CHEMBL1242478)
Affinity DataIC50:  0.603nMAssay Description:Inhibition of human VEGFR2 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50376024(CHEMBL259461)
Affinity DataIC50:  0.603nMAssay Description:Inhibition of human VEGFR2 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50376032(CHEMBL407715)
Affinity DataIC50:  0.708nMAssay Description:Inhibition of human VEGFR2 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50376023(CHEMBL408478)
Affinity DataIC50:  0.794nMAssay Description:Inhibition of human VEGFR2 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50376028(CHEMBL406388)
Affinity DataIC50:  0.794nMAssay Description:Inhibition of human VEGFR2 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50376020(CHEMBL269915)
Affinity DataIC50:  0.794nMAssay Description:Inhibition of human VEGFR2 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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