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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
61
hits in this display
Target
Rho-associated protein kinase 1
(Homo sapiens (Human))
Msd
Curated by
ChEMBL
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
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Affinity Data
Ki: 25.1nM
Assay Description:
Inhibition of ROCK-1
More data for this Ligand-Target Pair
Target Info
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Target
Rho-associated protein kinase 1
(Homo sapiens (Human))
Msd
Curated by
ChEMBL
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 40nM
Assay Description:
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...
More data for this Ligand-Target Pair
Target Info
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Target
Rho-associated protein kinase 2
(Homo sapiens (Human))
Kadmon
US Patent
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
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Affinity Data
Ki: 60nM
Assay Description:
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...
More data for this Ligand-Target Pair
Target Info
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Target
Rho-associated protein kinase 2
(Rattus norvegicus (Rat))
Temple University
Curated by
PDSP K
i
Database
Ligand
BDBM86729
((R)-(+)-trans-4-(1-aminoethyl)-N-(4-pyridyl)cycloh...)
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Affinity Data
Ki: 100nM
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Target
Rho-associated protein kinase 1
(Homo sapiens (Human))
Msd
Curated by
ChEMBL
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 140nM
Assay Description:
Inhibition of ROCK1 (unknown origin)
More data for this Ligand-Target Pair
Target Info
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Target
Rho-associated protein kinase 1
(Homo sapiens (Human))
Msd
Curated by
ChEMBL
Ligand
BDBM50319631
(CHEMBL1083134 | trans-4-[(1R)-1-Aminoethyl]-N-4-py...)
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Affinity Data
Ki: 140nM
Assay Description:
Inhibition of p160ROCK
Checked by Author
More data for this Ligand-Target Pair
Target Info
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Target
Rho-associated protein kinase 1
(Homo sapiens (Human))
Msd
Curated by
ChEMBL
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 140nM
Assay Description:
Inhibition of ROCK1 (unknown origin)
More data for this Ligand-Target Pair
Target Info
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Target
Rho-associated protein kinase 2
(Homo sapiens (Human))
Kadmon
US Patent
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
Copy SMILES
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Affinity Data
Ki: 140nM
Assay Description:
Inhibition of ROCK2 (unknown origin) assessed as inhibition constant
More data for this Ligand-Target Pair
Target Info
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Target
Rho-associated protein kinase 1
(Homo sapiens (Human))
Msd
Curated by
ChEMBL
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 150nM
Assay Description:
Inhibition of human leukocytic ROCK1 expressed in insect cells using KKRNRTLSV as substrate after 10 mins by pyruvate kinase/lactate dehydrogenase co...
More data for this Ligand-Target Pair
Target Info
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Target
Rho-associated protein kinase 1
(Homo sapiens (Human))
Msd
Curated by
ChEMBL
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 150nM ΔG°: -39.6kJ/mole
pH: 7.6 T: 2°C
Assay Description:
The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
Rho-associated protein kinase 1
(Homo sapiens (Human))
Msd
Curated by
ChEMBL
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 150nM
Assay Description:
Inhibition of human ROCK1 by homogenous luciferase assay
More data for this Ligand-Target Pair
Target Info
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KEGG
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Ligand Info
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PubMed
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3D Structure (crystal)
Copy BDB DOI
Target
Rho-associated protein kinase 1
(Homo sapiens (Human))
Msd
Curated by
ChEMBL
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 220nM
Assay Description:
Inhibition of ROCK1 (unknown origin)
More data for this Ligand-Target Pair
Target Info
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KEGG
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3D Structure (crystal)
Copy BDB DOI
Target
Rho-associated protein kinase 1
(Homo sapiens (Human))
Msd
Curated by
ChEMBL
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 220nM
Assay Description:
In vitro inhibition of angiotensin I converting enzyme in rabbit lung with hippuryl-histidyl-leucine as substrate
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
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3D Structure (crystal)
Copy BDB DOI
Target
Rho-associated protein kinase 2
(Homo sapiens (Human))
Kadmon
US Patent
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 300nM
Assay Description:
Inhibition of human ROCK2 by homogenous luciferase assay
More data for this Ligand-Target Pair
Target Info
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ChEBI
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PDB
3D Structure (crystal)
Copy BDB DOI
Target
Rho-associated protein kinase 2
(Homo sapiens (Human))
Kadmon
US Patent
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 300nM
Assay Description:
In vitro inhibition of angiotensin I converting enzyme in rabbit lung with hippuryl-histidyl-leucine as substrate
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
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Ligand Info
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ChEBI
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3D Structure (crystal)
Copy BDB DOI
Target
Rho-associated protein kinase 2
(Homo sapiens (Human))
Kadmon
US Patent
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 300nM
Assay Description:
Inhibition of ROCK2 (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
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antibodypedia
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ChEBI
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PDB
3D Structure (crystal)
Copy BDB DOI
Target
Rho-associated protein kinase 2
(Homo sapiens (Human))
Kadmon
US Patent
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 300nM
Assay Description:
Inhibition of ROCK2 (unknown origin)
More data for this Ligand-Target Pair
Target Info
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KEGG
UniProtKB/SwissProt
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ChEBI
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Copy BDB DOI
Target
Rho-associated protein kinase 2
(Homo sapiens (Human))
Kadmon
US Patent
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 300nM
Assay Description:
Inhibition of ROCK2 (unknown origin)
More data for this Ligand-Target Pair
Target Info
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3D Structure (crystal)
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Target
cAMP-dependent protein kinase catalytic subunit alpha
(Mus musculus (mouse))
Vertex Pharmaceuticals
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
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Affinity Data
Ki: >5.00E+3nM ΔG°: >-30.8kJ/mole
pH: 7.6 T: 2°C
Assay Description:
The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...
More data for this Ligand-Target Pair
Target Info
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Target
cAMP-dependent protein kinase catalytic subunit beta
(RAT)
Temple University
Curated by
PDSP K
i
Database
Ligand
BDBM86729
((R)-(+)-trans-4-(1-aminoethyl)-N-(4-pyridyl)cycloh...)
Copy SMILES
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Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
Target Info
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3D Structure (crystal)
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Target
Protein kinase C alpha type
(Rattus norvegicus (Rat))
Temple University
Curated by
PDSP K
i
Database
Ligand
BDBM86729
((R)-(+)-trans-4-(1-aminoethyl)-N-(4-pyridyl)cycloh...)
Copy SMILES
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Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
Target Info
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Msd
Curated by
ChEMBL
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
Copy SMILES
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Affinity Data
Ki: 7.94E+4nM
Assay Description:
Displacement of [3H]dofetilide from human ERG
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
Rho-associated protein kinase 2
(Homo sapiens (Human))
Kadmon
US Patent
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
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Affinity Data
IC50: 8.30nM
Assay Description:
Inhibition of ROCK2 (unknown origin) assessed as phosphorylation of MYPT1 using Tetramethylbenzidine as substrate in presence of ATP
More data for this Ligand-Target Pair
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Target
Rho-associated protein kinase 1
(Homo sapiens (Human))
Msd
Curated by
ChEMBL
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 46nM
Assay Description:
Inhibition of ROCK1
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
Rho-associated protein kinase 2
(Homo sapiens (Human))
Kadmon
US Patent
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
Copy SMILES
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Affinity Data
IC50: 54nM
Assay Description:
Inhibition of ROCK2 (unknown origin) using long S6 kinase peptide as substrate by radiometric assay
More data for this Ligand-Target Pair
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Target
Rho-associated protein kinase 2
(Homo sapiens (Human))
Kadmon
US Patent
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
Copy SMILES
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Affinity Data
IC50: 54nM
Assay Description:
Inhibition of human N-terminal GST-tagged ROCK2 expressed in baculovirus-infected insect cells using long S6 kinase peptide as substrate by radiometr...
More data for this Ligand-Target Pair
Target Info
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Target
Rho-associated protein kinase 2
(Homo sapiens (Human))
Kadmon
US Patent
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
Copy SMILES
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Affinity Data
IC50: 61nM
Assay Description:
Inhibition of ROCK2
More data for this Ligand-Target Pair
Target Info
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Target
Serine/threonine-protein kinase N2
(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
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Affinity Data
IC50: 70nM
Assay Description:
Inhibition of Prkcl2
More data for this Ligand-Target Pair
Target Info
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Target
Rho-associated protein kinase 2
(Homo sapiens (Human))
Kadmon
US Patent
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
Copy SMILES
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Affinity Data
IC50: 89nM
Assay Description:
Inhibition of human recombinant ROCK-2 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate after 40 mins by scintillation counting analysis
More data for this Ligand-Target Pair
Target Info
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3D Structure (crystal)
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Target
Rho-associated protein kinase 1
(Homo sapiens (Human))
Msd
Curated by
ChEMBL
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
Copy SMILES
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Affinity Data
IC50: 93nM
Assay Description:
Inhibition of ROCK-1 (unknown origin)
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Target
Rho-associated protein kinase 2
(Homo sapiens (Human))
Kadmon
US Patent
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
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Affinity Data
IC50: 143nM
Assay Description:
Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...
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Target
Rho-associated protein kinase 1
(Homo sapiens (Human))
Msd
Curated by
ChEMBL
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
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Affinity Data
IC50: 150nM
Assay Description:
Inhibition of human recombinant N-terminal his-tagged ROCK1 (3-543) expressed in baculovirus infected Sf9 cells using Biotin-Ahx-AKRRLSSLRA-CONH2 sub...
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Target
Rho-associated protein kinase 2
(Homo sapiens (Human))
Kadmon
US Patent
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
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Affinity Data
IC50: 245nM
Assay Description:
Inhibition of ROCK-2 by Immobilized metal ion affinity-based fluorescence polarization assay
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Target
Rho-associated protein kinase 2
(Homo sapiens (Human))
Kadmon
US Patent
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
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Affinity Data
IC50: 260nM
Assay Description:
Inhibition of human ROCK2 by IMAP assay
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Target
Protein kinase C epsilon type
(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
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Affinity Data
IC50: 335nM
Assay Description:
Inhibition of Prkce
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Target
Rho-associated protein kinase 2
(Bos taurus (bovine))
German Cancer Research Center
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
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Affinity Data
IC50: 500nM
Assay Description:
The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...
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Target
Serine/threonine-protein kinase N2
(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
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Affinity Data
IC50: 600nM
Assay Description:
Inhibition of His-tagged human PRK2 expressed in HEK293 cells
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Target
Serine/threonine-protein kinase N2
(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
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Affinity Data
IC50: 600nM
Assay Description:
Inhibition of Protein kinase C related kinase 2 (PRK2)
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Target
Rho-associated protein kinase 2
(Homo sapiens (Human))
Kadmon
US Patent
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
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Affinity Data
IC50: 700nM
Assay Description:
Inhibition of Protein kinase ROCK2 (ROCKII)
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Target
Rho-associated protein kinase 2
(Rattus norvegicus (Rat))
Temple University
Curated by
PDSP K
i
Database
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
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Affinity Data
IC50: 800nM
Assay Description:
Inhibition of rat ROCK2 expressed in Sf9 cells
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Target
Rho-associated protein kinase 1
(Homo sapiens (Human))
Msd
Curated by
ChEMBL
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
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Affinity Data
IC50: 871nM
Assay Description:
Inhibition of ROCK-1 by Immobilized metal ion affinity-based fluorescence polarization assay
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Target
Rho-associated protein kinase 1
(Homo sapiens (Human))
Msd
Curated by
ChEMBL
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
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Affinity Data
IC50: 1.13E+3nM
Assay Description:
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...
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Target
Rho-associated protein kinase 1
(Homo sapiens (Human))
Msd
Curated by
ChEMBL
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
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Affinity Data
IC50: 1.40E+3nM
Assay Description:
Inhibition of N terminal histidine tagged human recombinant ROCK1 (3 to 543 residues) expressed in baculovirus infected Sf9 cells using biotin-Ahx-AK...
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Target
Rho-associated protein kinase 2
(Homo sapiens (Human))
Kadmon
US Patent
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
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Affinity Data
IC50: 1.63E+3nM
Assay Description:
Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...
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Target
C-C motif chemokine 2
(Homo sapiens (Human))
Msd
Curated by
ChEMBL
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
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Affinity Data
IC50: 2.63E+3nM
Assay Description:
Inhibition of MCP1-mediated human THP cell migration
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Target
cAMP-dependent protein kinase catalytic subunit alpha [L49I,Q181K,T183A]
(Bos taurus (bovine))
German Cancer Research Center
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
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Affinity Data
IC50: 6.00E+3nM
Assay Description:
The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...
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Target
cAMP-dependent protein kinase catalytic subunit alpha [L49I,V123M,E127D,Q181K,T183A]
(Bos taurus (bovine))
German Cancer Research Center
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
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Affinity Data
IC50: 6.00E+3nM
Assay Description:
The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...
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Target
Myotonin-protein kinase
(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
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Affinity Data
IC50: >8.00E+3nM
Assay Description:
Inhibition of DMPK
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Target
Cell division control protein 42 homolog
(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
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Affinity Data
IC50: >8.00E+3nM
Assay Description:
Inhibition of CDc42
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Target
Ribosomal protein S6 kinase alpha-5
(Homo sapiens (Human))
University Of Dundee
Curated by
ChEMBL
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
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Affinity Data
IC50: 8.30E+3nM
Assay Description:
Inhibition of His-tagged human MSK1 expressed in Sf9 cells
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Target
cAMP-dependent protein kinase catalytic subunit alpha [Q181K,T183A]
(Bos taurus (bovine))
German Cancer Research Center
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
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Affinity Data
IC50: 9.00E+3nM
Assay Description:
The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...
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3D Structure (crystal)
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Target
cAMP-dependent protein kinase catalytic subunit alpha [T183A]
(Bos taurus (bovine))
German Cancer Research Center
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
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Affinity Data
IC50: 9.00E+3nM
Assay Description:
The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...
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Target
cAMP-dependent protein kinase catalytic subunit alpha [L49I,T183A]
(Bos taurus (bovine))
German Cancer Research Center
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
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Affinity Data
IC50: 1.20E+4nM
Assay Description:
The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...
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Target
cAMP-dependent protein kinase catalytic subunit alpha [E127D]
(Bos taurus (bovine))
German Cancer Research Center
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
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Affinity Data
IC50: 1.60E+4nM
Assay Description:
The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...
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Target
cAMP-dependent protein kinase catalytic subunit alpha [L49I,V123M,Q181K,T183A]
(Bos taurus (bovine))
German Cancer Research Center
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
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Affinity Data
IC50: 1.80E+4nM
Assay Description:
The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...
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Target
cAMP-dependent protein kinase catalytic subunit alpha [V123M,Q181K,T183A]
(Bos taurus (bovine))
German Cancer Research Center
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
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Affinity Data
IC50: 2.50E+4nM
Assay Description:
The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...
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Target
cAMP-dependent protein kinase catalytic subunit alpha [L49I]
(Bos taurus (bovine))
German Cancer Research Center
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
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Affinity Data
IC50: 2.80E+4nM
pH: 6.8 T: 2°C
Assay Description:
The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...
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Target
Rho-associated protein kinase 1
(Homo sapiens (Human))
Msd
Curated by
ChEMBL
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
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Affinity Data
IC50: 3.00E+4nM
Assay Description:
Inhibition of N terminal histidine tagged human recombinant ROCK1 (3 to 543 residues) in HASMC cells incubated for 2 hrs by ELISA method
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Target
cAMP-dependent protein kinase catalytic subunit alpha [V123M,T183A]
(Bos taurus (bovine))
German Cancer Research Center
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
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Affinity Data
IC50: 3.10E+4nM
Assay Description:
The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...
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Target
cAMP-dependent protein kinase catalytic subunit alpha
(Bos taurus (bovine))
German Cancer Research Center
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
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Affinity Data
IC50: 4.20E+4nM
pH: 6.8 T: 2°C
Assay Description:
The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...
More data for this Ligand-Target Pair
Target Info
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UniProtKB/SwissProt
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PubMed
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3D Structure (crystal)
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Target
cAMP-dependent protein kinase catalytic subunit alpha [V123M]
(Bos taurus (bovine))
German Cancer Research Center
Ligand
BDBM14029
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
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Affinity Data
IC50: 6.00E+4nM
pH: 6.8 T: 2°C
Assay Description:
The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
Purchase
ChEBI
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
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