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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
88
hits in this display
Target
Poly [ADP-ribose] polymerase 2
(Homo sapiens (Human))
Lupin
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.700nM
Assay Description:
Inhibition of N-terminal GST-tagged human PARP2 (2 to 583 residues) expressed in baculovirus infected Sf9 cells using histone mixture (H2A and H2B) a...
More data for this Ligand-Target Pair
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.40nM
Assay Description:
Inhibition of human full-length recombinant ARTD1 assessed as incorporation of [32P]NAD+ by scintillation counting analysis
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.40nM
Assay Description:
Inhibition of PARP1 (unknown origin)
More data for this Ligand-Target Pair
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.40nM
Assay Description:
Inhibition of PARP1 (unknown origin)
More data for this Ligand-Target Pair
Target Info
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MMDB
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UniProtKB/SwissProt
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antibodypedia
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.40nM
Assay Description:
Inhibition of human full-length recombinant PARP-1
More data for this Ligand-Target Pair
Target Info
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.40nM
Assay Description:
Inhibition of N-terminal GST-tagged human full length PARP1 (2 to 1041 residues) expressed in baculovirus infected Sf9 cells using histone mixture (H...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.40nM
Assay Description:
Binding affinity to PARP1 (unknown origin) assessed as inhibition constant
More data for this Ligand-Target Pair
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.40nM
Assay Description:
Inhibition of human recombinant full-length PARP1 after 4 mins by [32P]NAD+ incorporation assay
More data for this Ligand-Target Pair
Target Info
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.90nM
Assay Description:
Antagonist potency against histamine H3 receptor in an electrically stimulated guinea pig ileum
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Target
Poly [ADP-ribose] polymerase 2
(Homo sapiens (Human))
Lupin
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.400nM
Assay Description:
Inhibition of PARP2 (unknown origin)
More data for this Ligand-Target Pair
Target Info
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KEGG
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Copy BDB DOI
Target
Poly [ADP-ribose] polymerase 2
(Homo sapiens (Human))
Lupin
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.5nM
Assay Description:
Antagonist activity at human P2X7 receptor transfected in THP1 cells assessed as inhibition of benzoyl-ATP-induced changes in plasma membrane pore fo...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
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antibodypedia
GoogleScholar
Ligand Info
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MCE
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In Depth
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PubMed
Copy BDB DOI
Target
Poly [ADP-ribose] polymerase 2
(Homo sapiens (Human))
Lupin
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.5nM
Assay Description:
Inhibition of human PARP2 using NAD+ as substrate incubated for 1 hr by ELISA
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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MCE
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PC sid
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PubMed
Copy BDB DOI
Target
Poly [ADP-ribose] polymerase 2
(Homo sapiens (Human))
Lupin
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.5nM
Assay Description:
Inhibition of PARP2 (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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MCE
PC cid
PC sid
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In Depth
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Article
PubMed
Copy BDB DOI
Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.700nM
Assay Description:
Inhibition of N-terminal GST-tagged human full length PARP1 (2 to 1041 residues) expressed in baculovirus infected Sf9 cells using histone mixture (H...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
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MCE
PC cid
PC sid
PDB
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In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Poly [ADP-ribose] polymerase 2
(Homo sapiens (Human))
Lupin
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.800nM
Assay Description:
Inhibition of N-terminal GST-tagged human PARP2 (2 to 583 residues) expressed in baculovirus infected Sf9 cells using histone mixture (H2A and H2B) a...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
MCE
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.800nM
Assay Description:
Inhibition of PARP1 (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
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MCE
PC cid
PC sid
PDB
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In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.800nM
Assay Description:
Inhibition of human PARP1 using NAD+ as substrate incubated for 1 hr by ELISA
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
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MCE
PC cid
PC sid
PDB
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In Depth
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PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.800nM
Assay Description:
Antagonist activity at human P2X7 receptor transfected in THP1 cells assessed as inhibition of benzoyl-ATP-induced changes in plasma membrane pore fo...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
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MCE
PC cid
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PDB
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In Depth
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PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.800nM
Assay Description:
Inhibition of PARP1 (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
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MCE
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PubMed
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Copy BDB DOI
Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.804nM
Assay Description:
Inhibition of PARP1 (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
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MCE
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Copy BDB DOI
Target
Poly [ADP-ribose] polymerase 2
(Homo sapiens (Human))
Lupin
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.5nM
Assay Description:
Inhibition of PARP2 (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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DrugBank
antibodypedia
GoogleScholar
Ligand Info
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MCE
PC cid
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PubMed
Copy BDB DOI
Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.70nM
Assay Description:
Inhibition of PARP1 (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
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MCE
PC cid
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3D Structure (crystal)
Copy BDB DOI
Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2nM
Assay Description:
Inhibition of human PARP1 using [3H]NAD as substrate after 1 min by microplate scintillation counting analysis
More data for this Ligand-Target Pair
Target Info
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MMDB
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UniProtKB/SwissProt
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.10nM
Assay Description:
Inhibition of PARP1 was assessed using the Universal Chemiluminescent PARPKit. Luminescence readings were normalized to controls and fit to a sigmoid...
More data for this Ligand-Target Pair
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MMDB
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.20nM
Assay Description:
Inhibition of recombinant human His6-tagged PARP1 autophosphorylation at ADP-ribosyltransferase domain by LC-MS/MS method
More data for this Ligand-Target Pair
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.20nM
Assay Description:
Inhibition of full length recombinant human His6-tagged PARP1 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...
More data for this Ligand-Target Pair
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 4.70nM
Assay Description:
Inhibition of human recombinant full-length PARP1 after 4 mins by [32P]NAD+ incorporation assay
More data for this Ligand-Target Pair
Target Info
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MMDB
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UniProtKB/SwissProt
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 4.70nM
Assay Description:
Inhibition of PARP1 (unknown origin)
More data for this Ligand-Target Pair
Target Info
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MMDB
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UniProtKB/SwissProt
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antibodypedia
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 7nM
Assay Description:
Inhibition of human recombinant N-terminal 6His-6Lys-TEV tagged PARP1 full length expressed in pFastBac expression system incubated for 4 hrs by fluo...
More data for this Ligand-Target Pair
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 14nM
Assay Description:
Inhibition of human recombinant PARP1 by ELISA
More data for this Ligand-Target Pair
Target Info
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MMDB
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UniProtKB/SwissProt
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 24nM
Assay Description:
Inhibition of PARP1 (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
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MCE
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 26nM
Assay Description:
Inhibition of recombinant human GST-tagged PARP1 expressed in Escherichia coli using damaged DNA as substrate after 30 mins in presence of NAD+ by re...
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Target
Protein mono-ADP-ribosyltransferase PARP3
(Homo sapiens (Human))
TBA
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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Affinity Data
IC50: 28nM
Assay Description:
Antagonist activity at rat P2X7 receptor transfected in HEK cells assessed as inhibition of benzylATP-induced changes in plasma membrane pore formati...
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Target
Poly [ADP-ribose] polymerase 2
(Homo sapiens (Human))
Lupin
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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Affinity Data
IC50: 28nM
Assay Description:
Inhibition of full length recombinant human His6-tagged PARP2 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...
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Target
Poly [ADP-ribose] polymerase 2
(Homo sapiens (Human))
Lupin
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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Affinity Data
IC50: 39nM
Assay Description:
Inhibition of human recombinant PARP2 by ELISA
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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Affinity Data
IC50: 40nM
Assay Description:
Inhibition of recombinant human His6-tagged PARP1 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins foll...
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Target
Poly [ADP-ribose] polymerase 2
(Homo sapiens (Human))
Lupin
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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Affinity Data
IC50: 138nM
Assay Description:
Inhibition of full length recombinant human His6-tagged PARP2 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...
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Target
Poly [ADP-ribose] polymerase 2
(Homo sapiens (Human))
Lupin
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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Affinity Data
IC50: 138nM
Assay Description:
Inhibition of recombinant human His6-tagged PARP2 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins foll...
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Target
Poly [ADP-ribose] polymerase tankyrase-1
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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Affinity Data
IC50: 144nM
Assay Description:
Inhibition of recombinant human TNKS1 ADP-ribosyltransferase/sterile alpha motif domain expressed in Escherichia coli BL21(DE3) preincubated for 15 m...
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Target
Poly [ADP-ribose] polymerase tankyrase-1
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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Affinity Data
IC50: 145nM
Assay Description:
Inhibition of recombinant human TNKS1 ADP-ribosyltransferase/sterile alpha motif domain expressed in Escherichia coli BL21(DE3) preincubated for 15 m...
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Target
Poly [ADP-ribose] polymerase 2
(Homo sapiens (Human))
Lupin
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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Affinity Data
IC50: 172nM
Assay Description:
Inhibition of human recombinant N-terminal Avi-6His-TEV tagged PARP2 full length expressed in pFastBac expression system incubated for 4 hrs by fluor...
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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Affinity Data
IC50: 301nM
Assay Description:
Inhibition of recombinant human His6-tagged PARP1 C-3-zinc finger domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by...
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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Affinity Data
IC50: 302nM
Assay Description:
Inhibition of recombinant human His6-tagged PARP1 C-3-zinc finger domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by...
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Target
Protein mono-ADP-ribosyltransferase PARP3
(Homo sapiens (Human))
TBA
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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Affinity Data
IC50: 407nM
Assay Description:
Inhibition of full length recombinant human His6-tagged PARP3 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...
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Target
Protein mono-ADP-ribosyltransferase PARP3
(Homo sapiens (Human))
TBA
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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Affinity Data
IC50: 407nM
Assay Description:
Inhibition of full length recombinant human His6-tagged PARP3 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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Affinity Data
IC50: >500nM
Assay Description:
Inhibition of PARP1 (unknown origin)
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Target
Protein mono-ADP-ribosyltransferase PARP10
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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Affinity Data
IC50: 562nM
Assay Description:
Inhibition of full length recombinant human His6-tagged PARP10 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinyla...
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Target
Protein mono-ADP-ribosyltransferase PARP10
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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Affinity Data
IC50: 562nM
Assay Description:
Inhibition of full length recombinant human His6-tagged PARP10 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinyla...
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Target
Protein mono-ADP-ribosyltransferase PARP10
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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Affinity Data
IC50: 570nM
Assay Description:
Inhibition of full length recombinant human His6-tagged PARP10 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinyla...
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Target
Protein mono-ADP-ribosyltransferase PARP4
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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Affinity Data
IC50: 832nM
Assay Description:
Inhibition of recombinant human His6-tagged PARP4 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins foll...
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Target
Protein mono-ADP-ribosyltransferase PARP4
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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Affinity Data
IC50: 839nM
Assay Description:
Inhibition of recombinant human His6-tagged PARP4 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins foll...
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Target
Poly [ADP-ribose] polymerase tankyrase-2
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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Affinity Data
IC50: 890nM
Assay Description:
Inhibition of recombinant human TNKS2 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biot...
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Target
Poly [ADP-ribose] polymerase tankyrase-2
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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Affinity Data
IC50: 891nM
Assay Description:
Inhibition of recombinant human TNKS2 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biot...
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Target
Dual specificity tyrosine-phosphorylation-regulated kinase 1B
(Homo sapiens (Human))
TBA
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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Affinity Data
IC50: 1.94E+3nM
Assay Description:
Inhibition of recombinant human DYRK1B expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scin...
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Target
Protein mono-ADP-ribosyltransferase PARP10
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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Affinity Data
IC50: 2.31E+3nM
Assay Description:
Inhibition of recombinant human His6-tagged PARP10 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins fol...
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Target
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human))
TBA
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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Affinity Data
IC50: 2.36E+3nM
Assay Description:
Inhibition of recombinant human DYRK1A expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scin...
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Target
Protein mono-ADP-ribosyltransferase PARP12
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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Affinity Data
IC50: 6.61E+3nM
Assay Description:
Inhibition of recombinant human His6-tagged PARP12 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins fol...
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Target
Protein mono-ADP-ribosyltransferase PARP12
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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Affinity Data
IC50: 6.65E+3nM
Assay Description:
Inhibition of recombinant human His6-tagged PARP12 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins fol...
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Target
Dual specificity tyrosine-phosphorylation-regulated kinase 3
(Homo sapiens (Human))
TBA
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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Affinity Data
IC50: 8.03E+3nM
Assay Description:
Inhibition of recombinant human DYRK3 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scint...
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Target
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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Affinity Data
IC50: 8.83E+3nM
Assay Description:
Inhibition of recombinant human His6-tagged PARP14 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins fol...
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Target
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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IC50: 8.91E+3nM
Assay Description:
Inhibition of recombinant human His6-tagged PARP14 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins fol...
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Target
Glycogen synthase kinase-3 beta
(Homo sapiens (Human))
TBA
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of recombinant human GSK-3beta expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric s...
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Target
Dual specificity tyrosine-phosphorylation-regulated kinase 4
(Homo sapiens (Human))
TBA
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of recombinant human DYRK4 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scint...
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Target
Dual specificity tyrosine-phosphorylation-regulated kinase 2
(Homo sapiens (Human))
TBA
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of recombinant human DYRK2 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scint...
More data for this Ligand-Target Pair
Target Info
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Target
Dual specificity protein kinase CLK4
(Homo sapiens (Human))
TBA
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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IC50: >1.00E+4nM
Assay Description:
Inhibition of recombinant human CLK4 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...
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Dual specificity protein kinase CLK3
(Homo sapiens (Human))
TBA
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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IC50: >1.00E+4nM
Assay Description:
Inhibition of recombinant human CLK3 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...
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Dual specificity protein kinase CLK2
(Homo sapiens (Human))
TBA
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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IC50: >1.00E+4nM
Assay Description:
Inhibition of recombinant human CLK2 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...
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Dual specificity protein kinase CLK1
(Homo sapiens (Human))
TBA
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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IC50: >1.00E+4nM
Assay Description:
Inhibition of recombinant human CLK1 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...
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Target
Casein kinase I isoform epsilon
(Homo sapiens (Human))
TBA
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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IC50: >1.00E+4nM
Assay Description:
Inhibition of recombinant human CK1epsilon expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric ...
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Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse))
TBA
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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IC50: >1.00E+4nM
Assay Description:
Inhibition of recombinant human CDK5/p25 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric sc...
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GDH/6PGL endoplasmic bifunctional protein
(Homo sapiens (Human))
H. Lee Moffitt Cancer Center & Research Institute
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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IC50: 1.80E+4nM
Assay Description:
HEK293 H6PD-OE and HEK293 pellets were lysed and the lysate was quantified with the Bradford protein assay. Reaction mix containing galactose-6-phosp...
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Target
Protein mono-ADP-ribosyltransferase PARP15
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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IC50: 3.24E+4nM
Assay Description:
Inhibition of recombinant human His6-tagged PARP15 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins fol...
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Target
Protein mono-ADP-ribosyltransferase PARP15
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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IC50: 3.26E+4nM
Assay Description:
Inhibition of recombinant human His6-tagged PARP15 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins fol...
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Poly [ADP-ribose] polymerase tankyrase-1
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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Affinity Data
IC50: 3.70E+4nM
Assay Description:
Inhibition of human recombinant PARP5a (E1023 to T1327 amino acids) incubated for 4 hrs by fluorescence anisotropy binding assay
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Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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EC50: 4.70nM
Assay Description:
Inhibition of PARP in human LoVo cells assessed as inhibition of poly(ADP)-ribose polymerization for 30 mins by fluorescence assay
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Target
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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Kd: >1.00E+4nM
Assay Description:
Binding affinity to PARP14 (unknown origin) assessed as apparent dissociation constant
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Protein mono-ADP-ribosyltransferase PARP12
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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Kd: >1.00E+4nM
Assay Description:
Binding affinity to PARP12 (unknown origin) assessed as apparent dissociation constant
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Protein mono-ADP-ribosyltransferase PARP11
(Homo sapiens)
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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Kd: >1.00E+4nM
Assay Description:
Binding affinity to PARP11 (unknown origin) assessed as apparent dissociation constant
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Protein mono-ADP-ribosyltransferase PARP10
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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Kd: 3.10E+3nM
Assay Description:
Binding affinity to PARP10 (unknown origin) assessed as apparent dissociation constant
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Protein mono-ADP-ribosyltransferase PARP9
(Homo sapiens)
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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Kd: 3.10E+3nM
Assay Description:
Binding affinity to PARP9 (unknown origin) assessed as apparent dissociation constant
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Protein mono-ADP-ribosyltransferase PARP8
(Homo sapiens)
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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Kd: >1.00E+4nM
Assay Description:
Binding affinity to PARP8 (unknown origin) assessed as apparent dissociation constant
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Poly [ADP-ribose] polymerase tankyrase-1
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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Kd: >1.00E+4nM
Assay Description:
Binding affinity to PARP5a (unknown origin) assessed as apparent dissociation constant
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Protein mono-ADP-ribosyltransferase PARP4
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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Kd: 503nM
Assay Description:
Binding affinity to PARP4 (unknown origin) assessed as apparent dissociation constant
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Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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EC50: 17nM
Assay Description:
Inhibition of human PARP-1 catalytic domain (662 to 1011 residues) expressed in Escherichia coli BL21(DE3) cells incubated for 0.5 hrs by fluorescenc...
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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Kd: 3.20nM
Assay Description:
Binding affinity to PARP1 (unknown origin) assessed as apparent dissociation constant
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Target
Protein mono-ADP-ribosyltransferase PARP3
(Homo sapiens (Human))
TBA
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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Kd: 267nM
Assay Description:
Binding affinity to PARP3 (unknown origin) assessed as apparent dissociation constant
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Protein mono-ADP-ribosyltransferase PARP16
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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Kd: 2.90E+3nM
Assay Description:
Binding affinity to PARP16 (unknown origin) assessed as apparent dissociation constant
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Target
Poly [ADP-ribose] polymerase 2
(Homo sapiens (Human))
Lupin
Curated by
ChEMBL
Ligand
BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
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Kd: 26nM
Assay Description:
Binding affinity to PARP2 (unknown origin) assessed as apparent dissociation constant
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