Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 3 hits in this display   

TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

LigandBDBM50380614(CHEMBL2016634)Copy SMILESCopy InChI

Affinity DataIC50:  272nMAssay Description:Inhibition of GST-tagged TNKS2P catalytic domain autoPARsylation measuring nicotinamide concentration after 2 hrs by LC-MS analysisMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

LigandBDBM50380614(CHEMBL2016634)Copy SMILESCopy InChI

Affinity DataIC50:  1.01E+3nMAssay Description:Inhibition of GST-tagged TNKS1P catalytic domain autoPARsylation measuring nicotinamide concentration after 2 hrs by LC-MS analysisMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetProtein Wnt-3a(Mus musculus)
Novartis Institutes For Biomedical Research

Curated by ChEMBL

LigandBDBM50380614(CHEMBL2016634)Copy SMILESCopy InChI

Affinity DataIC50:  1.06E+3nMAssay Description:Inhibition of mouse Wnt3A signaling in human HEK293 cells after 1 day by super top flash luciferase reporter gene assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI