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Target
Protein Wnt-3a
Ligand
BDBM50380614
Substrate
n/a
Meas. Tech.
ChEMBL_813156 (CHEMBL2020822)
IC50
1060±n/a nM
Citation
 Shultz, MD; Kirby, CA; Stams, T; Chin, DN; Blank, J; Charlat, O; Cheng, H; Cheung, A; Cong, F; Feng, Y; Fortin, PD; Hood, T; Tyagi, V; Xu, M; Zhang, B; Shao, W [1,2,4]triazol-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: antagonists of the Wnt pathway that inhibit tankyrases 1 and 2 via novel adenosine pocket binding. J Med Chem 55:1127-36 (2012) [PubMed]  Article 
Target
Name:
Protein Wnt-3a
Synonyms:
WNT3A_MOUSE | Wnt-3a | Wnt3a | protein Wnt-3a precursor
Type:
PROTEIN
Mol. Mass.:
39269.29
Organism:
Mus musculus
Description:
ChEMBL_813156
Residue:
352
Sequence:
MAPLGYLLVLCSLKQALGSYPIWWSLAVGPQYSSLSTQPILCASIPGLVPKQLRFCRNYVEIMPSVAEGVKAGIQECQHQFRGRRWNCTTVSNSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGSAAICGCSSRLQGSPGEGWKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRTIGDFLKDKYDSASEMVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARTERRREKCHCVFHWCCYVSCQECTRVYDVHTCK
  
Inhibitor
Name:
BDBM50380614
Synonyms:
CHEMBL2016634
Type:
Small organic molecule
Emp. Form.:
C23H18N6O2S
Mol. Mass.:
442.493
SMILES:
COc1ccc(cc1)-n1c(SCc2nc(no2)-c2ccccc2)nnc1-c1ccncc1
Structure:
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