Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 35 hits in this display
BDBM50044784(CHEBI:79090 | SB-202190 | US10865384, Compound SB2...)
BDBM50044784(CHEBI:79090 | SB-202190 | US10865384, Compound SB2...)
BDBM50044784(CHEBI:79090 | SB-202190 | US10865384, Compound SB2...)
BDBM50044784(CHEBI:79090 | SB-202190 | US10865384, Compound SB2...)
BDBM50044784(CHEBI:79090 | SB-202190 | US10865384, Compound SB2...)
BDBM50044784(CHEBI:79090 | SB-202190 | US10865384, Compound SB2...)
BDBM50044784(CHEBI:79090 | SB-202190 | US10865384, Compound SB2...)
BDBM50044784(CHEBI:79090 | SB-202190 | US10865384, Compound SB2...)
BDBM50044784(CHEBI:79090 | SB-202190 | US10865384, Compound SB2...)
BDBM50044784(CHEBI:79090 | SB-202190 | US10865384, Compound SB2...)
IC50: 30nMAssay Description:Inhibition of tyrosinase in mouse B16F10 cells assessed as reduction in melanin synthesis after 2 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
BDBM50044784(CHEBI:79090 | SB-202190 | US10865384, Compound SB2...)
IC50: 30nMAssay Description:Inhibition of tyrosinase in mouse B16F10 cells assessed as reduction in melanin synthesis after 2 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
BDBM50044784(CHEBI:79090 | SB-202190 | US10865384, Compound SB2...)
BDBM50044784(CHEBI:79090 | SB-202190 | US10865384, Compound SB2...)
BDBM50044784(CHEBI:79090 | SB-202190 | US10865384, Compound SB2...)
BDBM50044784(CHEBI:79090 | SB-202190 | US10865384, Compound SB2...)
IC50: 53nMAssay Description:Table 2: The p38 MAPK IC50 values of selected compounds except IM-32 to IM-44 were determined using the HitHunter™ p38 MAP kinase binding assay from ...More data for this Ligand-Target Pair
BDBM50044784(CHEBI:79090 | SB-202190 | US10865384, Compound SB2...)
BDBM50044784(CHEBI:79090 | SB-202190 | US10865384, Compound SB2...)
BDBM50044784(CHEBI:79090 | SB-202190 | US10865384, Compound SB2...)
IC50: 83nMAssay Description:Table 2: The p38 MAPK IC50 values of selected compounds except IM-32 to IM-44 were determined using the HitHunter™ p38 MAP kinase binding assay from ...More data for this Ligand-Target Pair
BDBM50044784(CHEBI:79090 | SB-202190 | US10865384, Compound SB2...)
IC50: 83nMAssay Description:Table 3: Small molecules were tested for their inhibitory activities towards casein kinase 1 delta (CK1δ) and 1 epsilon (CK1ϵ). The in vit...More data for this Ligand-Target Pair
BDBM50044784(CHEBI:79090 | SB-202190 | US10865384, Compound SB2...)
BDBM50044784(CHEBI:79090 | SB-202190 | US10865384, Compound SB2...)
BDBM50044784(CHEBI:79090 | SB-202190 | US10865384, Compound SB2...)
BDBM50044784(CHEBI:79090 | SB-202190 | US10865384, Compound SB2...)
BDBM50044784(CHEBI:79090 | SB-202190 | US10865384, Compound SB2...)
BDBM50044784(CHEBI:79090 | SB-202190 | US10865384, Compound SB2...)
IC50: 2.50E+3nMAssay Description:Inhibition of human N-terminal His6-tagged BRDT (21 to 137 residues) expressed in Escherichia coli BL21 (DE3) cells incubated for 1 hrMore data for this Ligand-Target Pair
BDBM50044784(CHEBI:79090 | SB-202190 | US10865384, Compound SB2...)
BDBM50044784(CHEBI:79090 | SB-202190 | US10865384, Compound SB2...)
BDBM50044784(CHEBI:79090 | SB-202190 | US10865384, Compound SB2...)
BDBM50044784(CHEBI:79090 | SB-202190 | US10865384, Compound SB2...)
BDBM50044784(CHEBI:79090 | SB-202190 | US10865384, Compound SB2...)
BDBM50044784(CHEBI:79090 | SB-202190 | US10865384, Compound SB2...)
BDBM50044784(CHEBI:79090 | SB-202190 | US10865384, Compound SB2...)
BDBM50044784(CHEBI:79090 | SB-202190 | US10865384, Compound SB2...)
BDBM50044784(CHEBI:79090 | SB-202190 | US10865384, Compound SB2...)
Kd: 3.40E+3nMAssay Description:Binding affinity to recombinant human His6-TEV protease-tagged BRD4 bromodomain 1 expressed in bacteria by isothermal titration calorimetric methodMore data for this Ligand-Target Pair
BDBM50044784(CHEBI:79090 | SB-202190 | US10865384, Compound SB2...)
Kd: 3.42E+3nMAssay Description:Binding affinity to human N-terminal His6-tagged BRDTexpressed in Escherichia coli BL21 (DE3) cells (21 to 137 residues) incubated for 1 hrMore data for this Ligand-Target Pair