Affinity DataKi: 7.38E+3nMAssay Description:Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2C expressed in Xeno...More data for this Ligand-Target Pair
Affinity DataKi: 7.40E+3nMAssay Description:To determine the affinity of the compounds of the present invention a SPA is used. The assay is run in a 384-plate format (OptiPlate-384) where each ...More data for this Ligand-Target Pair
Affinity DataKi: 8.49E+3nMAssay Description:Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2C expressed in Xeno...More data for this Ligand-Target Pair
Affinity DataKi: 8.67E+3nMAssay Description:Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2C expressed in Xeno...More data for this Ligand-Target Pair
Affinity DataKi: 8.70E+3nMAssay Description:Antagonist activity rat recombinant GluN1/GluN2C receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response by...More data for this Ligand-Target Pair
Affinity DataKi: 8.98E+3nMAssay Description:Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2C expressed in Xeno...More data for this Ligand-Target Pair
Affinity DataKi: 9.00E+3nMAssay Description:Antagonist activity rat recombinant GluN1/GluN2C receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response by...More data for this Ligand-Target Pair
Affinity DataKi: 2.14E+4nMAssay Description:Antagonist activity rat recombinant GluN1/GluN2C receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response by...More data for this Ligand-Target Pair
Affinity DataKi: 2.40E+4nMAssay Description:Antagonist activity at recombinant rat GluN1a/GluN2C expressed in Xenopus laevis oocytes assessed as inhibition of glycine/glutamate-mediated current...More data for this Ligand-Target Pair
Affinity DataKi: 2.70E+4nMAssay Description:Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2C expressed in Xeno...More data for this Ligand-Target Pair
Affinity DataKi: 2.80E+4nMAssay Description:Antagonist activity rat recombinant GluN1/GluN2C receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response by...More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+5nMAssay Description:Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2C expressed in Xeno...More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+5nMAssay Description:Antagonist activity rat recombinant GluN1/GluN2C receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response by...More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+5nMAssay Description:Antagonist activity rat recombinant GluN1/GluN2C receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response by...More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+5nMAssay Description:Antagonist activity rat recombinant GluN1/GluN2C receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response by...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2C(Homo sapiens (Human))
Academy of Sciences of The Czech Republic V.V.I.
Curated by ChEMBL
Academy of Sciences of The Czech Republic V.V.I.
Curated by ChEMBL
Affinity DataIC50: 400nMAssay Description:Inhibition of recombinant GluN1/GluN2C receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of glutamate-evoked current by whol...More data for this Ligand-Target Pair
Affinity DataIC50: 900nMAssay Description:Negative allosteric modulation of rat GluN1a/GluN2C receptor expressed in Xenopus laevis oocytes assessed as suppression of 100 uM glutamate and 30 u...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...More data for this Ligand-Target Pair
Affinity DataIC50: 2.40E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN1/GluN2C expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induce...More data for this Ligand-Target Pair
Affinity DataIC50: 2.40E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN1/GluN2C expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induce...More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...More data for this Ligand-Target Pair
Affinity DataIC50: 3.20E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN1/GluN2C expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induce...More data for this Ligand-Target Pair
Affinity DataIC50: 3.70E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN1/GluN2C expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induce...More data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+3nMAssay Description:Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...More data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+3nMAssay Description:Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...More data for this Ligand-Target Pair
Affinity DataIC50: 5.29E+3nMAssay Description:Mean inhibitory concentration against rat N-methyl-D-aspartate (NMDA) glutamate receptor 1a/2C expressed in Xenopus oocytesMore data for this Ligand-Target Pair
Affinity DataIC50: 6.00E+3nMAssay Description:Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...More data for this Ligand-Target Pair
Affinity DataIC50: 6.00E+3nMAssay Description:Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...More data for this Ligand-Target Pair
Affinity DataIC50: 6.00E+3nMAssay Description:Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...More data for this Ligand-Target Pair
Affinity DataIC50: 6.50E+3nMAssay Description:Negative allosteric modulation of rat GluN1/GluN2C expressed in Xenopus laevis oocytes assessed as inhibition of L-glutamate/glycine-induced current ...More data for this Ligand-Target Pair
Affinity DataIC50: 7.00E+3nMAssay Description:Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...More data for this Ligand-Target Pair
Affinity DataIC50: 7.90E+3nMAssay Description:Negative allosteric modulation of rat GluN1/GluN2C expressed in Xenopus laevis oocytes assessed as inhibition of L-glutamate/glycine-induced current ...More data for this Ligand-Target Pair
Affinity DataIC50: 8.00E+3nMAssay Description:Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...More data for this Ligand-Target Pair
Affinity DataIC50: 8.00E+3nMAssay Description:Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...More data for this Ligand-Target Pair
Affinity DataIC50: 8.20E+3nMAssay Description:Negative allosteric modulation of rat GluN1/GluN2C expressed in Xenopus laevis oocytes assessed as inhibition of L-glutamate/glycine-induced current ...More data for this Ligand-Target Pair
Affinity DataIC50: 8.60E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN1/GluN2C expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induce...More data for this Ligand-Target Pair
Affinity DataIC50: 9.00E+3nMAssay Description:Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...More data for this Ligand-Target Pair
Affinity DataIC50: 9.00E+3nMAssay Description:Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...More data for this Ligand-Target Pair
Affinity DataIC50: 9.00E+3nMAssay Description:Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2C(Homo sapiens (Human))
Academy of Sciences of The Czech Republic V.V.I.
Curated by ChEMBL
Academy of Sciences of The Czech Republic V.V.I.
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Negative allosteric modulation of recombinant human GluN1a/GluN2C expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...More data for this Ligand-Target Pair