Compile Data Set for Download or QSAR
maximum 50k data
Found 26 Enz. Inhib. hit(s) with all data for entry = 50016861
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50597843(CHEMBL5203393)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of DYRK1A (unknown origin) using KKISGRLSPIMTEQ as substrate incubated for 30 mins in presence of ATP by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM251574(US9452998, Table 4 Compound 4)
Affinity DataIC50:  3nMAssay Description:Inhibition of GSK-3-beta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50097869(CHEMBL3589662)
Affinity DataIC50:  6nMAssay Description:Inhibition of DYRK1A (unknown origin) using KKISGRLSPIMTEQ as substrate incubated for 30 mins in presence of ATP by ADP-Glo assayMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50597836(CHEMBL5186778)
Affinity DataIC50:  6nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50520332(CHEMBL4530280)
Affinity DataIC50:  10nMAssay Description:Displacement of [gamma-33P]-ATP from GST-fused recombinant human DYRK1A expressed in Escherichia coli using GRSRSRSRSRSR as substrate incubated for 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50597844(CHEMBL5208531)
Affinity DataIC50: >10nMAssay Description:Inhibition of DYRK1A (unknown origin) using KKISGRLSPIMTEQ as substrate incubated for 30 mins in presence of ATP by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50597847(CHEMBL4798624)
Affinity DataIC50:  11nMAssay Description:Inhibition of GST-fused recombinant human DYRK1A expressed in Escherichia coli using KKISGRLSPIMTEQ as substrate in presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50597845(CHEMBL5205235)
Affinity DataIC50:  12nMAssay Description:Inhibition of GST-fused recombinant human DYRK1A expressed in Escherichia coli using KKISGRLSPIMTEQ as substrate in presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM100152(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
Affinity DataIC50:  12nMAssay Description:Inhibition of N-terminal GST-fused full-length human DYRK1A (1 to 763 residues) expressed in baculovirus expression system using myelin basic protein...More data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50597847(CHEMBL4798624)
Affinity DataIC50:  18nMAssay Description:Inhibition of GST-fused recombinant human CLK1 expressed in Escherichia coli using GRSRSRSRSRSR as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
LigandPNGBDBM50466858(CHEMBL4292553)
Affinity DataIC50:  21nMAssay Description:Inhibition of 6xHis-tagged rat DYRK1A (1 to 502 residues) expressed in Escherichia coli BL21(DE3) using FKHR as substrate incubated for 30 mins in pr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM251574(US9452998, Table 4 Compound 4)
Affinity DataIC50:  39nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50597840(CHEMBL5207883)
Affinity DataIC50:  40nMAssay Description:Displacement of [gamma-33P]-ATP from GST-fused recombinant human DYRK1A expressed in Escherichia coli using GRSRSRSRSRSR as substrate incubated for 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50597837(CHEMBL5196629)
Affinity DataIC50:  57nMAssay Description:Inhibition of 6xHis-tagged rat DYRK1A (1 to 502 residues) expressed in Escherichia coli BL21(DE3) using FKHR as substrate incubated for 30 mins in pr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50597841(CHEMBL5198172)
Affinity DataIC50:  70nMAssay Description:Displacement of [gamma-33P]-ATP from GST-fused recombinant human DYRK1A expressed in Escherichia coli using GRSRSRSRSRSR as substrate incubated for 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50597835(CHEMBL5196635)
Affinity DataIC50:  74nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50597846(CHEMBL5183410)
Affinity DataIC50:  113nMAssay Description:Inhibition of GST-fused recombinant human DYRK1A expressed in Escherichia coli using KKISGRLSPIMTEQ as substrate in presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50597842(CHEMBL5186380)
Affinity DataIC50:  200nMAssay Description:Inhibition of DYRK1A (unknown origin) using KKISGRLSPIMTEQ as substrate incubated for 30 mins in presence of ATP by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50597833(CHEMBL5189503)
Affinity DataIC50:  243nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50597839(CHEMBL5188914)
Affinity DataIC50:  410nMAssay Description:Displacement of [gamma-33P]-ATP from GST-fused recombinant human DYRK1A expressed in Escherichia coli using GRSRSRSRSRSR as substrate incubated for 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50597834(CHEMBL5192413)
Affinity DataIC50:  1.07E+3nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50597838(CHEMBL5174603)
Affinity DataIC50:  1.10E+3nMAssay Description:Displacement of [gamma-33P]-ATP from GST-fused recombinant human DYRK1A expressed in Escherichia coli using GRSRSRSRSRSR as substrate incubated for 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50597845(CHEMBL5205235)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of GST-fused recombinant human CLK1 expressed in Escherichia coli using GRSRSRSRSRSR as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50520328(CHEMBL4542402)
Affinity DataIC50:  3.30E+3nMAssay Description:Displacement of [gamma-33P]-ATP from GST-fused recombinant human DYRK1A expressed in Escherichia coli using GRSRSRSRSRSR as substrate incubated for 3...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50597846(CHEMBL5183410)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of GST-fused recombinant human CLK1 expressed in Escherichia coli using GRSRSRSRSRSR as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50325939(CHEMBL611368 | Licocoumarone)
Affinity DataIC50:  1.26E+4nMAssay Description:Inhibition of N-terminal 6His-tagged recombinant human DYRK1A (674 to 763 residues) expressed in Escherichia coli BL21(DE3) using RARPGTPALRE as subs...More data for this Ligand-Target Pair
In DepthDetails PubMed