Compile Data Set for Download or QSAR
maximum 50k data
Found 495 of ic50 for UniProtKB: P21860
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataIC50:  0.190nMAssay Description:Inhibition of GST-tagged human recombinant EGFR catalytic domain (668 to 1210 amino acids) T790M/L858R mutant expressed in Sf9 cells pre-incubated fo...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM5447(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) after 1.5 hrs by FRET-based Z'Lyte assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM50123453(CHEMBL3623290)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of EGFR exon19 deletion mutant (unknown origin) by HTRF assay in presence of Km of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM50123453(CHEMBL3623290)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) by HTRF assay in presence of Km of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM50183383(CHEMBL3818547)
Affinity DataIC50:  0.310nMAssay Description:Inhibition of recombinant human EGFR L858R mutant expressed in baculovirus infected insect cells preincubated for 5 mins followed by ATP addition for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM50183406(CHEMBL3818062)
Affinity DataIC50:  0.350nMAssay Description:Inhibition of recombinant human EGFR L858R mutant expressed in baculovirus infected insect cells preincubated for 5 mins followed by ATP addition for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM50183388(CHEMBL3818015)
Affinity DataIC50:  0.380nMAssay Description:Inhibition of recombinant human EGFR L858R mutant expressed in baculovirus infected insect cells preincubated for 5 mins followed by ATP addition for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM50166941(CHEMBL3797606)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of EGFR T790M/L858R mutant (unknown origin) expressed in baculovirus expression system after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataIC50:  0.420nMAssay Description:Inhibition of GST-tagged human recombinant EGFR catalytic domain (668 to 1210 amino acids) L858R mutant expressed in Sf9 cells pre-incubated for 30 m...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)
Affinity DataIC50:  0.570nMAssay Description:Inhibition of EGFR exon 19 deletion activating mutant phosphorylation in human PC9 cells after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of EGFR T790M mutant (unknown origin) incubated for 1 hr by spectrophotometric analysisMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM112499(DACOMITINIB | US8623883, No. 2 | WO2022090481, Exa...)
Affinity DataIC50:  0.630nMAssay Description:Inhibition of EGFR exon 19 deletion activating mutant phosphorylation in human PC9 cells after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM5447(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)
Affinity DataIC50:  0.637nMAssay Description:Inhibition of cytoplasmic GST-tagged human recombinant EGFR L858R mutant expressed in baculovirus system by z-lyte assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataIC50:  0.660nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM195875(US9670213, Compound 020 N-(3-(2-(4-(4-methyl-1-pip...)
Affinity DataIC50:  0.677nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM50166942(CHEMBL3798501)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of EGFR T790M/L858R mutant (unknown origin) expressed in baculovirus expression system after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM50183391(CHEMBL3818563)
Affinity DataIC50:  0.710nMAssay Description:Inhibition of recombinant human EGFR L858R mutant expressed in baculovirus infected insect cells preincubated for 5 mins followed by ATP addition for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of EGFR L858R/T90M double mutant (unknown origin) after 1.5 hrs by FRET-based Z'Lyte assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM50183395(CHEMBL3818289)
Affinity DataIC50:  0.830nMAssay Description:Inhibition of recombinant human EGFR L858R mutant expressed in baculovirus infected insect cells preincubated for 5 mins followed by ATP addition for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)
Affinity DataIC50:  0.970nMAssay Description:Inhibition of wild type EGFR T790M mutant (unknown origin) incubated for 5 mins by HTRF assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM50177903(CHEMBL3814825)
Affinity DataIC50: <1nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human EGFR T790M/L858R double mutant using biotinylated TK substrate incubated for 50 mins by HTRF as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM195887(US9670213, Compound 032 N-(3-(2-(2-methoxy-4-(4-me...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of EGFR T790M/L858R mutant (unknown origin) incubated for 1 hr by spectrophotometric analysisMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM195875(US9670213, Compound 020 N-(3-(2-(4-(4-methyl-1-pip...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM50166944(CHEMBL3799864)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of EGFR T790M/L858R mutant (unknown origin) expressed in baculovirus expression system after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM50029689(CHEMBL3353411)
Affinity DataIC50:  2nMAssay Description:Inhibition of EGFR Del ex19 mutant phosphorylation in human PC9 cells preincubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM50029689(CHEMBL3353411)
Affinity DataIC50:  2nMAssay Description:Inhibition of EGFR T790M/L858R double mutant phosphorylation in human H1975 cells preincubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM50033377(CHEMBL3357649)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of wild type EGFR T790M mutant (unknown origin) incubated for 5 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM50123453(CHEMBL3623290)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of EGFR exon19 deletion mutant (unknown origin) by HTRF assay in presence of 2mM of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM5447(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of EGFR tyrosine kinase L858R mutant (unknown origin) assessed as ATP level by luminescence analysisMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM195887(US9670213, Compound 032 N-(3-(2-(2-methoxy-4-(4-me...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM50166949(CHEMBL3798128)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of EGFR T790M/L858R mutant (unknown origin) expressed in baculovirus expression system after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM195873(US9670213, Compound 018 N-(3-(2-(4-morpholinopheny...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM50453891(CHEMBL4214567)
Affinity DataIC50:  3nMAssay Description:Inhibition of human GST-fused EGFR T790M/C797S double mutant expressed in Sf9 insect cells by HTRF assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM50494218(CHEMBL3086102)
Affinity DataIC50:  3nMAssay Description:Inhibition of EGFR L851Q mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM50494218(CHEMBL3086102)
Affinity DataIC50:  3nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM4779(CHEMBL31965 | CHEMBL545315 | CI-1033 | Canertinib ...)
Affinity DataIC50:  3nMAssay Description:Inhibition of EGFR L858R/T790M double mutant autophosphorylation in human NCI-H1975 cells after 2 hrs by sandwich ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM50033388(CHEMBL3357652)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of wild type EGFR T790M mutant (unknown origin) incubated for 5 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM50187717(CHEMBL3828269)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of cytoplasmic GST-tagged human recombinant EGFR L858R mutant expressed in baculovirus system by z-lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM50166945(CHEMBL3798887)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of EGFR T790M/L858R mutant (unknown origin) expressed in baculovirus expression system after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM50166950(CHEMBL3799428)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of EGFR T790M/L858R mutant (unknown origin) expressed in baculovirus expression system after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM50033374(CHEMBL3357637)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of wild type EGFR T790M mutant (unknown origin) incubated for 5 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM195880(US9670213, Compound 025 4-(8-(3-acrylamidephenyl)-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM50159347(CHEMBL3787662 | US9586965, Cpd 1)
Affinity DataIC50:  4nMAssay Description:Inhibition of EGFR L858R/T790M double mutant autophosphorylation in human NCI-H1975 cells after 2 hrs by sandwich ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM50187719(CHEMBL3828021)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of cytoplasmic GST-tagged human recombinant EGFR L858R mutant expressed in baculovirus system by z-lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM50166948(CHEMBL3799255)
Affinity DataIC50:  4.40nMAssay Description:Inhibition of EGFR T790M/L858R mutant (unknown origin) expressed in baculovirus expression system after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM195879(US9670213, Compound 024 N-(3-(2-(4-(acetylamino)-p...)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM50147001(CHEMBL3763405)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of recombinant human EGFR L858R/T790M double mutant assessed as reduction in autophosphorylation of cytoplasmic domain by Z'-Lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM195878(US9670213, Compound 023 N-(3-(2-(4-(diethylamino)p...)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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