Compile Data Set for Download or QSAR
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Found 5 Enz. Inhib. hit(s) with Target = 'Androgen receptor' and Ligand = 'BDBM50158077'
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50158077((2S,6R)-4-(3-Trifluoromethyl-phenyl)-4-aza-tricycl...)
Affinity DataKi:  7nMAssay Description:Inhibition of [3H]-DHT binding to T877A androgen receptor of LNCaP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50158077((2S,6R)-4-(3-Trifluoromethyl-phenyl)-4-aza-tricycl...)
Affinity DataKi:  632nMAssay Description:Inhibition of [3H]-DHT binding to androgen receptor of MDA-453 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50158077((2S,6R)-4-(3-Trifluoromethyl-phenyl)-4-aza-tricycl...)
Affinity DataIC50:  35nMAssay Description:Inhibition of T877A androgen receptor of human prostate cancer cells in reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50158077((2S,6R)-4-(3-Trifluoromethyl-phenyl)-4-aza-tricycl...)
Affinity DataIC50:  410nMAssay Description:Inhibition of L701H/T877A mutant androgen receptor of human prostate cancer MDAMB-PCa2b cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50158077((2S,6R)-4-(3-Trifluoromethyl-phenyl)-4-aza-tricycl...)
Affinity DataIC50:  744nMAssay Description:Inhibition of human androgen receptor of breast carcinoma MDA-453 cells in reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed