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Found 5 Enz. Inhib. hit(s) with Target = 'Beta-secretase 1' and Ligand = 'BDBM15799'
TargetBeta-secretase 1(Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM15799(CHEMBL81671 | Macrocyclic BACE inhibitor 1 | tert-...)
Affinity DataIC50:  82nMpH: 4.6 T: 2°CAssay Description:The substrate is linked to a fluorescent dye on one end and to a quenching group on its other end. The fluorescence of the substrate is significantly...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM15799(CHEMBL81671 | Macrocyclic BACE inhibitor 1 | tert-...)
Affinity DataIC50:  82nMAssay Description:In vitro inhibition of Beta-secretase-1 in HEK293 (Human Embryonic Kidney) cell line.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM15799(CHEMBL81671 | Macrocyclic BACE inhibitor 1 | tert-...)
Affinity DataIC50:  82nMAssay Description:In vitro inhibitory activity against Beta-secretase 1 in human HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM15799(CHEMBL81671 | Macrocyclic BACE inhibitor 1 | tert-...)
Affinity DataIC50:  82nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM15799(CHEMBL81671 | Macrocyclic BACE inhibitor 1 | tert-...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of BACE1 by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed