Found 17 Enz. Inhib. hit(s) with Target = 'Bifunctional dihydrofolate reductase-thymidylate synthase' and Ligand = 'BDBM18050' TargetBifunctional dihydrofolate reductase-thymidylate synthase(Leishmania major)
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataKi: 0.129nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorChecked by AuthorMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University
Curated by ChEMBL
University
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Inhibitory activity against Dihydrofolate reductase from Toxoplasma gondii was evaluated using 90 microM dihydrofolic acid as substrateMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University
Curated by ChEMBL
University
Curated by ChEMBL
Affinity DataIC50: 11nMpH: 7.4 T: 2°CAssay Description:DHFRs were assayed spectrophotometrically in the reaction buffer solution containing dihydrofolate. The reaction was initiated with an amount of enzy...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University
Curated by ChEMBL
University
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University
Curated by ChEMBL
University
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of T. gondii Dihydrofolate reductaseMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University
Curated by ChEMBL
University
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibitory concentration of the compound for DHFR in Toxoplasma gondiiMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University
Curated by ChEMBL
University
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of Toxoplasma gondii (tc) Dihydrofolate reductaseMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University
Curated by ChEMBL
University
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibitory activity against Toxoplasma gondii dihydrofolate reductase (in 90 microM dihydrofolic acid)More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University
Curated by ChEMBL
University
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition against Dihydrofolate reductase in Toxoplasma gondiiMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University
Curated by ChEMBL
University
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Inhibitory activity of the compound against Toxoplasma gondii dihydrofolate reductase (in 50 microM dihydrofolic acid)More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University
Curated by ChEMBL
University
Curated by ChEMBL
Affinity DataIC50: 33nMAssay Description:Inhibition of Toxoplasma gondii DHFRMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University
Curated by ChEMBL
University
Curated by ChEMBL
Affinity DataIC50: 33nMAssay Description:Inhibition of Toxoplasma gondii DHFRMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University
Curated by ChEMBL
University
Curated by ChEMBL
Affinity DataIC50: 33nMAssay Description:DHFRs were assayed spectrophotometrically in the reaction buffer solution containing dihydrofolate. The reaction was initiated with an amount of enzy...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University
Curated by ChEMBL
University
Curated by ChEMBL
Affinity DataIC50: 33nMAssay Description:DHFRs were assayed spectrophotometrically in the reaction buffer solution containing dihydrofolate. The reaction was initiated with an amount of enzy...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University
Curated by ChEMBL
University
Curated by ChEMBL
Affinity DataIC50: 71nMAssay Description:Inhibition of Toxoplasma gondii TS-DHFR expressed in Escherichia coli BL21 preincubated for 15 mins followed by addition of DHF as substrate and NADP...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University
Curated by ChEMBL
University
Curated by ChEMBL
Affinity DataIC50: 1.80E+4nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University
Curated by ChEMBL
University
Curated by ChEMBL
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of Toxoplasma gondii thymidylate synthaseMore data for this Ligand-Target Pair
