Found 14 Enz. Inhib. hit(s) with Target = 'Broad substrate specificity ATP-binding cassette transporter ABCG2' and Ligand = 'BDBM32628' TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Hungarian Academy Of Sciences
Curated by ChEMBL
Hungarian Academy Of Sciences
Curated by ChEMBL
Affinity DataKi: 1.30E+3nMAssay Description:TP_TRANSPORTER: inhibition of ATPase in membrane vesicle from BCRP-expressing Sf9 cellsMore data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Hungarian Academy Of Sciences
Curated by ChEMBL
Hungarian Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 321nMAssay Description:Inhibition of human adenosine kinase activityMore data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Hungarian Academy Of Sciences
Curated by ChEMBL
Hungarian Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 451nMAssay Description:Inhibition of ABCG2 in human H460/MX20 cells assessed as potentiation of mitoxantrone induced antiproliferative activity by measuring mitoxantrone IC...More data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Hungarian Academy Of Sciences
Curated by ChEMBL
Hungarian Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 470nMAssay Description:Inhibition of human ABCG2 expressed in dog MDCK-II-BCRP cells mediated pheophorbide A efflux preincubated with PhA followed by compound addition and ...More data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Hungarian Academy Of Sciences
Curated by ChEMBL
Hungarian Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 612nMAssay Description:Inhibition of human DNA polymerase deltaMore data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Hungarian Academy Of Sciences
Curated by ChEMBL
Hungarian Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 730nMAssay Description:Inhibition of ABCG2 in human MCF7/Topo cells by Hoechst 33342 assayMore data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Hungarian Academy Of Sciences
Curated by ChEMBL
Hungarian Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 731nMAssay Description:Inhibition of ABCG2 in human MCF7/Topo cells after 2 hrs by Hoechst 33342 microplate assayMore data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Hungarian Academy Of Sciences
Curated by ChEMBL
Hungarian Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 731nMAssay Description:Inhibition of ABCG2 in human MCF7/Topo cells after 2 hrs by Hoechst 33342 staining based fluorescence assayMore data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Hungarian Academy Of Sciences
Curated by ChEMBL
Hungarian Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 790nMpH: 7.4 T: 2°CAssay Description:IC50 and maximal activities for inhibition of PhA accumulation were determined from dose-response curves. The accumulation of PhA, a fluorescent ABCG...More data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Hungarian Academy Of Sciences
Curated by ChEMBL
Hungarian Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:Inhibition of ABCG2 expressed in human NCI-H460 cells assessed as inhibition of PhA accumulation after 2 to 20 hrs relative to fumitremorgin CMore data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Hungarian Academy Of Sciences
Curated by ChEMBL
Hungarian Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 960nMAssay Description:Inhibition of BCRP in human MCF7/Topo cells assessed as mitoxantrone accumulation preincubated for 10 mins followed by mitoxantrone addition measured...More data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Hungarian Academy Of Sciences
Curated by ChEMBL
Hungarian Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 1.48E+3nMAssay Description:Inhibition of ABCG2 in topotecan-cultured human MCF7 cells using Hoechst 33342 as substrate measured after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Hungarian Academy Of Sciences
Curated by ChEMBL
Hungarian Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: >1.10E+4nMAssay Description:Inhibition of ABCG2 overexpressed in human MCF7/Topo cells by flow cytometric-based mitoxantrone efflux assayMore data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Hungarian Academy Of Sciences
Curated by ChEMBL
Hungarian Academy Of Sciences
Curated by ChEMBL
Affinity DataEC50: 1.00E+3nMAssay Description:Inhibition of BCRP (unknown origin)More data for this Ligand-Target Pair
