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Found 2 Enz. Inhib. hit(s) with Target = 'Caspase-1' and Ligand = 'BDBM50453029'
TargetCaspase-1(Homo sapiens (Human))
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453029(CHEMBL4216115)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of human recombinant caspase-1 using AC-WEHD-AMC as substrate at Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453029(CHEMBL4216115)
Affinity DataIC50:  27nMAssay Description:Inhibition of caspase-1 in human THP1 cells assessed as decrease in LPS-induced IL-1beta secretion after overnight incubation by sandwich immunoassayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed