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Found 3 Enz. Inhib. hit(s) with Target = 'Caspase-3' and Ligand = 'BDBM10339'
TargetCaspase-3(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM10339((S)-1-Methyl-5-(2-phenoxymethyl-azetidine-1-sulfon...)
Affinity DataIC50:  91.2nMAssay Description:Inhibition of caspase3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM10339((S)-1-Methyl-5-(2-phenoxymethyl-azetidine-1-sulfon...)
Affinity DataIC50:  91.7nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM10339((S)-1-Methyl-5-(2-phenoxymethyl-azetidine-1-sulfon...)
Affinity DataEC50:  3.25E+3nMAssay Description:Inhibition of staurosporine induced activation of caspase 3 activation in human Hela cells assessed as hydrolysis of Z-DEVD-R110 substrate by micropl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed