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Found 2 Enz. Inhib. hit(s) with Target = 'Cyclin-dependent kinase 12' and Ligand = 'BDBM50367676'
TargetCyclin-dependent kinase 12(Homo sapiens)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50367676(CHEMBL4160662)
Affinity DataIC50:  195nMAssay Description:Inhibition of CDK12 in human SK-BR-3 cells assessed as reduction in RNA polymerase 2 Ser2 phosphorylation incubated for 4 hrs byMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 12(Homo sapiens)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50367676(CHEMBL4160662)
Affinity DataKd:  16nMAssay Description:Binding affinity to human CDK12 (715 to 1052 residues)/CyclinK (1 to 267 residues) expressed in baculovirus infected in Sf9 cells by Biolayer interfe...More data for this Ligand-Target Pair
In DepthDetails PubMed