Compile Data Set for Download or QSAR
maximum 50k data
Found 3 Enz. Inhib. hit(s) with Target = 'DNA (cytosine-5)-methyltransferase 1' and Ligand = 'BDBM491120'
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
Glaxosmithkline Intellectual Property Development

US Patent
LigandPNGBDBM491120((R)-2-((3,5-dicyano-6-(dimethylamino)-4-ethylpyrid...)
Affinity DataIC50:  89nMAssay Description:This assay used Scintillation Proximity technology in a signal increase format to evaluate the potency of compounds. Full-length human DNMT1, hemi-me...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
Glaxosmithkline Intellectual Property Development

US Patent
LigandPNGBDBM491120((R)-2-((3,5-dicyano-6-(dimethylamino)-4-ethylpyrid...)
Affinity DataIC50: <320nMAssay Description:Biochemical activity of DNMT1 analyzed using SPA technology. Plates (Griener 784075) were pre-stamped with 100 nL/well of compound (11-point, 3-fold ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
Glaxosmithkline Intellectual Property Development

US Patent
LigandPNGBDBM491120((R)-2-((3,5-dicyano-6-(dimethylamino)-4-ethylpyrid...)
Affinity DataIC50: <320nMAssay Description:Biochemical activity of DNMT1 analyzed using SPA technology. Plates (Griener 784075) were pre-stamped with 100 nL/well of compound (11-point, 3-fold ...More data for this Ligand-Target Pair
In DepthDetails US Patent