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Found 9 Enz. Inhib. hit(s) with Target = 'DNA (cytosine-5)-methyltransferase 1' and Ligand = 'BDBM50430056'
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50430056(CHEMBL2336409 | SGI-1027)
Affinity DataIC50:  382nMAssay Description:Inhibition of DNMT1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50430056(CHEMBL2336409 | SGI-1027)
Affinity DataIC50:  850nMAssay Description:Inhibition of human N-terminal 600 residues-deleted DNMT1 using poly(dI-dC) as substrate in presence of AdoMetMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50430056(CHEMBL2336409 | SGI-1027)
Affinity DataIC50:  3.55E+3nMAssay Description:Inhibition of human DNMT1 using polydeoxyinosine polydeoxycytosine DNA as substrate after 15 mins in presence of SAM by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50430056(CHEMBL2336409 | SGI-1027)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of His6-tagged human recombinant DNMT1 expressed in insect Sf9 cells assessed as reduction in DNA methyltransferase activity using 5'-biot...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50430056(CHEMBL2336409 | SGI-1027)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of human DNMT1 using hemimethylated DNA as substrate by radioactive methyl transfer assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50430056(CHEMBL2336409 | SGI-1027)
Affinity DataIC50:  1.12E+4nMAssay Description:Inhibition of human DNMT1 using AdoMet and poly dI-dC after 2 hrs by radioactive assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50430056(CHEMBL2336409 | SGI-1027)
Affinity DataIC50:  1.25E+4nMAssay Description:Inhibition of human DNMT1 using polydeoxyinosine polydeoxycytosine DNA as substrate by radioactive methyl transfer assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50430056(CHEMBL2336409 | SGI-1027)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition of human N-terminal 600 residues-deleted DNMT1 using hemimethylated (GAC)12 as substrate preincubated for 5 mins followed by substrate add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50430056(CHEMBL2336409 | SGI-1027)
Affinity DataEC50:  1.02E+4nMAssay Description:Inhibition of human His-DNMT1 using [methyl-3H]SAM as substrate after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed