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Found 3 Enz. Inhib. hit(s) with Target = 'Dihydrofolate reductase' and Ligand = 'BDBM50067861'
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50067861(CHEMBL140940 | N*6*-Methyl-N*6*-phenyl-pyrido[3,2-...)
Affinity DataIC50:  1.30nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) from rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50067861(CHEMBL140940 | N*6*-Methyl-N*6*-phenyl-pyrido[3,2-...)
Affinity DataIC50:  99.5nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) from Pneumocystis cariniiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50067861(CHEMBL140940 | N*6*-Methyl-N*6*-phenyl-pyrido[3,2-...)
Affinity DataIC50:  942nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in consumption of NADPH using 9 uM DHFA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed