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Found 4 Enz. Inhib. hit(s) with Target = 'Dihydrofolate reductase' and Ligand = 'BDBM50128530'
TargetDihydrofolate reductase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128530(5-(6,7-Dimethoxy-1-methyl-3,4-dihydro-1H-isoquinol...)
Affinity DataIC50:  44nMAssay Description:Antibacterial activity of the compound against TMP-susceptible Dihydrofolate reductase from Staphylococcus pneumoniae ATCC 49619More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128530(5-(6,7-Dimethoxy-1-methyl-3,4-dihydro-1H-isoquinol...)
Affinity DataIC50:  53nMAssay Description:Inhibitory activity against TMP-susceptible Dihydrofolate reductase from Staphylococcus pneumoniae ATCC 49619More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128530(5-(6,7-Dimethoxy-1-methyl-3,4-dihydro-1H-isoquinol...)
Affinity DataIC50:  670nMAssay Description:Antibacterial activity against TMP-Resistance Dihydrofolate reductase from Staphylococcus pneumoniae 1/1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus (strain MW2))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128530(5-(6,7-Dimethoxy-1-methyl-3,4-dihydro-1H-isoquinol...)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibitory activity against TMP-Resistance Dihydrofolate reductase from Staphylococcus aureus 157/4696More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed