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Found 5 Enz. Inhib. hit(s) with Target = 'Dihydrofolate reductase' and Ligand = 'BDBM50329610'
TargetDihydrofolate reductase(Bacillus anthracis)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50329610(6-ethyl-5-(3-(4-methoxybiphenyl-3-yl)prop-1-ynyl)p...)
Affinity DataKi:  1.21E+3nMAssay Description:Inhibition of wild type Bacillus anthracis recombinant DHFRMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Staphylococcus aureus)
University of Connecticut

US Patent
LigandPNGBDBM50329610(6-ethyl-5-(3-(4-methoxybiphenyl-3-yl)prop-1-ynyl)p...)
Affinity DataIC50:  2.40nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third generation analogs were evaluated in enzyme inhibition assays, assessed for S. aur...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Streptococcus pyogenes)
University of Connecticut

US Patent
LigandPNGBDBM50329610(6-ethyl-5-(3-(4-methoxybiphenyl-3-yl)prop-1-ynyl)p...)
Affinity DataIC50:  5.90nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third generation analogs were evaluated in enzyme inhibition assays, assessed for S. aur...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydrofolate reductase(Homo sapiens (Human))
University of Connecticut

US Patent
LigandPNGBDBM50329610(6-ethyl-5-(3-(4-methoxybiphenyl-3-yl)prop-1-ynyl)p...)
Affinity DataIC50:  300nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third generation analogs were evaluated in enzyme inhibition assays, assessed for S. aur...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydrofolate reductase(Bacillus anthracis)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50329610(6-ethyl-5-(3-(4-methoxybiphenyl-3-yl)prop-1-ynyl)p...)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of wild type Bacillus anthracis recombinant DHFRMore data for this Ligand-Target Pair