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Found 4 Enz. Inhib. hit(s) with Target = 'Estrogen receptor' and Ligand = 'BDBM50336730'
TargetEstrogen receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50336730(4-[4-(2,4-Dioxothiazolidin-5-ylidenemethyl)-2-meth...)
Affinity DataIC50:  2.20E+3nMAssay Description:Binding affinity to ERalpha by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50336730(4-[4-(2,4-Dioxothiazolidin-5-ylidenemethyl)-2-meth...)
Affinity DataIC50: >6.30E+3nMAssay Description:Antagonist activity at ERalpha by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50336730(4-[4-(2,4-Dioxothiazolidin-5-ylidenemethyl)-2-meth...)
Affinity DataIC50: >1.50E+4nMAssay Description:Antagonist activity at human ERalpha LBD in human MCF7 cells assessed as inhibition of estradiol-induced cell proliferation after up to 6 days by cel...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50336730(4-[4-(2,4-Dioxothiazolidin-5-ylidenemethyl)-2-meth...)
Affinity DataEC50: >1.50E+4nMAssay Description:Agonist activity at human ERalpha LBD in human MCF7 cells assessed as induction of cell proliferation after up to 6 days by celltiter-glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed