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Found 6 Enz. Inhib. hit(s) with Target = 'Glycogen synthase kinase-3 beta' and Ligand = 'BDBM50150699'
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50150699(3-(9-fluoro-2-(piperidine-1-carbonyl)-1,2,3,4-tetr...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of Glycogen synthase kinase-3 beta dependent Tau protein serine-396 phosphorylation in human SY5Y cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50150699(3-(9-fluoro-2-(piperidine-1-carbonyl)-1,2,3,4-tetr...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of human GSK-3beta using YRRAAVPPSPSLSRHSSPHQ(pS)EDEEE as substrate measured in presence of [gamma-33P]ATP by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50150699(3-(9-fluoro-2-(piperidine-1-carbonyl)-1,2,3,4-tetr...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50150699(3-(9-fluoro-2-(piperidine-1-carbonyl)-1,2,3,4-tetr...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human GSK3betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50150699(3-(9-fluoro-2-(piperidine-1-carbonyl)-1,2,3,4-tetr...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human Glycogen synthase kinase-3 betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50150699(3-(9-fluoro-2-(piperidine-1-carbonyl)-1,2,3,4-tetr...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human GSK-3beta H350L mutant (2 to end residues) at 10 uM using phospho GS2 peptide as substrate after 40 mins by [gamma-33ATP] radiome...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed