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Found 8 Enz. Inhib. hit(s) with Target = 'Histamine H3 receptor' and Ligand = 'BDBM50224190'
TargetHistamine H3 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224190((R)-2-(1,3-dimethyl-1H-pyrazol-4-yl)-6-(2-(2-methy...)
Affinity DataKi:  0.450nMAssay Description:Displacement of [3H]-N-alpha methyl histamine from human H3 receptor expressed in C6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224190((R)-2-(1,3-dimethyl-1H-pyrazol-4-yl)-6-(2-(2-methy...)
Affinity DataKi:  0.450nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human cloned histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224190((R)-2-(1,3-dimethyl-1H-pyrazol-4-yl)-6-(2-(2-methy...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [125I]Iodoproxyfan from human recombinant histamine H3 receptor by Competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224190((R)-2-(1,3-dimethyl-1H-pyrazol-4-yl)-6-(2-(2-methy...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from rat cloned histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224190((R)-2-(1,3-dimethyl-1H-pyrazol-4-yl)-6-(2-(2-methy...)
Affinity DataKi:  1.62nMAssay Description:Displacement of [3H]-N-alpha methyl histamine from rat H3 receptor expressed in C6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224190((R)-2-(1,3-dimethyl-1H-pyrazol-4-yl)-6-(2-(2-methy...)
Affinity DataKi:  3.09nMAssay Description:Antagonist activity at rat histamine H3 receptor expressed in HEK239 cells assessed as inhibition of RAMH-stimulated [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224190((R)-2-(1,3-dimethyl-1H-pyrazol-4-yl)-6-(2-(2-methy...)
Affinity DataEC50:  5.75nMAssay Description:Agonist activity at rat histamine H3 receptor expressed in HEK239 cells assessed as reduction of basal [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224190((R)-2-(1,3-dimethyl-1H-pyrazol-4-yl)-6-(2-(2-methy...)
Affinity DataEC50:  2nMAssay Description:Agonist activity at human histamine H3 receptor expressed in HEK239 cells assessed as reduction of basal [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed