Found 41 Enz. Inhib. hit(s) with Target = 'Histone deacetylase 8' and Ligand = 'BDBM50005711' 
Affinity DataKi: 45nMAssay Description:Inhibition of C-terminal His-tagged human recombinant full-length HDAC8 expressed in baculovirus expression system assessed as reduction in 7-amino-4...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 45nMAssay Description:Inhibition of human HDAC8More data for this Ligand-Target Pair
Affinity DataKi: 70nMAssay Description:Inhibition of human recombinant HDAC8 by Michaelis-Menten equation analysisMore data for this Ligand-Target Pair
Affinity DataKi: 145nMAssay Description:Inhibition of recombinant human C-terminal His-tagged HDAC8 (1 to 377 residues) expressed in baculovirus-infected insect cells using RHK(Ac)K(Ac)AMC ...More data for this Ligand-Target Pair
Affinity DataIC50: 70.1nMpH: 8.0Assay Description:Briefly, recombinant HDACs and substrates were diluted in reaction buffer (50 mM Tris-HCl, pH 8.0, 137 mM NaCl, 2.7mM KCl, 1mM MgCl2, 1 mg/ml BSA, 1%...More data for this Ligand-Target Pair
Affinity DataIC50: 90nMAssay Description:Inhibition of human HDAC8 using fluorogenic tetrapeptide RHKKAc as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 125nMAssay Description:Inhibition of HDAC8 (unknown origin) by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Inhibition of HDAC8 (unknown origin) incubated for 1 hr by fluor de lys substrate based fluorescence methodMore data for this Ligand-Target Pair
Affinity DataIC50: 165nMAssay Description:HDAC enzyme inhibition assays were performed using purified HDACs 1-10 essentially as described in Beckers et al., 2007, Int. J. Cancer., 121:1138-48...More data for this Ligand-Target Pair
Affinity DataIC50: 170nMAssay Description:Inhibition of HDAC8 (unknown origin) using RHK(Ac)K(Ac) fluorogenic acetylated peptide substrate by fluorometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 175nMAssay Description:The IC50 values for aforementioned compounds against HDACs were determined. HDAC 1 to 11 can be assayed by using acetylated AMC-labeled peptide subst...More data for this Ligand-Target Pair
Affinity DataIC50: 175nMAssay Description:The IC50 values for aforementioned compounds against HDACs were determined. HDAC 1 to 11 can be assayed by using acetylated AMC-labeled peptide subst...More data for this Ligand-Target Pair
Affinity DataIC50: 213nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair
Affinity DataIC50: 232nMAssay Description:Inhibition of recombinant full-length human HDAC8 using RHKK(Ac) as substrate measured after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 280nMAssay Description:Inhibition of human recombinant HDAC8 after 30 mins using fluorogenic substrate by fluorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 290nMAssay Description:Inhibition of HDAC8 (unknown origin) by colorimetric methodMore data for this Ligand-Target Pair
Affinity DataIC50: 307nMAssay Description:Inhibition of human recombinant C-terminal His-tagged HDAC8 (1 to 377 residues) expressed in insect cells using RHK-K(Ac)-K(Ac)-AMC as substrate incu...More data for this Ligand-Target Pair
Affinity DataIC50: 310nMAssay Description:Inhibition of human full-length C-terminal His-tagged HDAC8 expressed in baculovirus infected Sf9 insect cell using fluorogenic HDAC class 2a substra...More data for this Ligand-Target Pair
Affinity DataIC50: 314nMAssay Description:Inhibition of human recombinant HDAC8 using [RHKK(Ac)] fluorogenic substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 314nMAssay Description:Inhibition of recombinant human HDAC8 using fluorogenic substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 360nMAssay Description:Inhibition of recombinant human HDAC8 by fluorimetryMore data for this Ligand-Target Pair
Affinity DataIC50: 366nMAssay Description:The inhibitory activity of panobinostat dissolved in DMSO and that of the HP-β-CD panobinostat adduct (prepared as described in Example 1) were ...More data for this Ligand-Target Pair
Affinity DataIC50: 371nMAssay Description:Inhibition of recombinant C-terminal His-fusion tagged and N-terminal Streptavidin2-tagged human HDAC8 (1 to 377 residues) expressed in insect cells ...More data for this Ligand-Target Pair
Affinity DataIC50: 420nMAssay Description:Inhibition of human full-length recombinant C-terminal His-tagged HDAC8 expressed in baculovirus infected Sf9 insect cells preincubated for 5 mins fo...More data for this Ligand-Target Pair
Affinity DataIC50: 427nMAssay Description:Inhibition of human HDAC8 using RHKAcKAc as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 472nMAssay Description: I. Compound handling: Testing compounds were dissolved in 100% DMSO to a specific concentration. The serial dilution was conducted by epMotion 5070 ...More data for this Ligand-Target Pair
Affinity DataIC50: 490nMAssay Description:Inhibition of recombinant human full length C-terminal His-tagged HDAC8 expressed in baculovirus infected Sf9 cells using fluorogenic HDAC class2a as...More data for this Ligand-Target Pair
Affinity DataIC50: 550nMAssay Description:HDAC reactions were assembled in 384 well plates (Greiner) in a total volume of 20 μL as follows: HDAC proteins (and their regulatory subunit, i...More data for this Ligand-Target Pair
Affinity DataIC50: 566nMAssay Description:Inhibition of human HDAC8 using RHKAcKAc peptide as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 609nMAssay Description:Inhibition of C-terminal His-tagged recombinant human HDAC8 expressed in baculovirus infected insect cells using RHKK(Ac)AMC as substrate by fluoresc...More data for this Ligand-Target Pair
Affinity DataIC50: 650nMAssay Description:Inhibition of recombinant human C-terminal His-tagged HDAC8 (1 to 377 residues) expressed in insect cells using RHK-K(Ac)-AMC as substrate measured a...More data for this Ligand-Target Pair
Affinity DataIC50: 697nMAssay Description:Inhibition of recombinant C-terminal His-fusion tagged/N-terminal Strep2 tagged human HDAC8 (1 to 377 residues) expressed in insect cells using RHK-K...More data for this Ligand-Target Pair
Affinity DataIC50: 790nMAssay Description:Inhibition of HDAC8 (unknown origin) measured by fluorometry assayMore data for this Ligand-Target Pair
Affinity DataIC50: 820nMAssay Description:Inhibition of recombinant human HDAC8 using RHK-K(Ac)-AMC as substrate by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 944nMAssay Description:Inhibition of recombinant C-terminal His-tagged and N-terminal Streptavidin2-tagged human HDAC8 (1 to 377 residues) expressed in baculovirus infected...More data for this Ligand-Target Pair
Affinity DataIC50: 990nMAssay Description:Inhibition of recombinant C-terminal His-tagged human HDAC8 (1 to 377 residues) expressed in Baculovirus infected insect cells using RHK-K(Ac)-AMC as...More data for this Ligand-Target Pair
Affinity DataIC50: 1.02E+3nMAssay Description:Inhibition of human HDAC8 using RHKAcKAc as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 1.16E+3nMAssay Description:Inhibition of HDAC8 (unknown origin) using Fluor de lys as substrate by fluorescence based analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.36E+3nMAssay Description:Inhibition of HDAC8 (unknown origin) after 30 mins by fluorometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 3.62E+3nMAssay Description:Inhibition of Schistosoma mansoni KDAC8 using (FAM)-labeled peptide as substrate after 60 mins by microfluidic assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.55E+3nMAssay Description:Inhibition of human KDAC8 using [3H]acetyl histone H4 peptide substrate incubated for 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
