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Found 3 Enz. Inhib. hit(s) with Target = 'Indoleamine 2,3-dioxygenase 1' and Ligand = 'BDBM370526'
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Newlink Genetics

Curated by ChEMBL
LigandPNGBDBM370526(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5- yl)et...)
Affinity DataIC50:  45nMAssay Description:Inhibition of purified human IDO1 using L-tryptophan as substrate preincubated for 5 mins followed by substrate addition and measured after 15 mins b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Newlink Genetics

Curated by ChEMBL
LigandPNGBDBM370526(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5- yl)et...)
Affinity DataIC50: <1.00E+3nMAssay Description:The IC50 values for each compound were determined by testing the activity of IDO in a mixture containing 50 mM potassium phosphate buffer at pH 6.5; ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Newlink Genetics

Curated by ChEMBL
LigandPNGBDBM370526(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5- yl)et...)
Affinity DataEC50:  59nMAssay Description:Inhibition of recombinant human IDO1 expressed in T-REx-293 cells assessed as reduction in kynurenine level measured after 16 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed