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Found 4 Enz. Inhib. hit(s) with Target = 'Integrin alpha-V/beta-3' and Ligand = 'BDBM50390492'
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50390492(CHEMBL2071605)
Affinity DataKi:  2.27nMAssay Description:Displacement of [125I]-c(RGDyK) from human integrin alphavbeta3 after 16 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50390492(CHEMBL2071605)
Affinity DataIC50:  3.52nMAssay Description:Displacement of [125I]-c(RGDyK) from human integrin alphavbeta3 after 16 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50390492(CHEMBL2071605)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of alphavbeta3 integrin receptor-mediated cell adhesion to vitronectin in human WM 266-4 cells preincubated for 30 mins followed by VN sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50390492(CHEMBL2071605)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of alphavbeta3 integrin receptor-mediated cell adhesion to vitronectin in human A549 cells preincubated for 30 mins followed by VN substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed