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Found 3 Enz. Inhib. hit(s) with Target = 'Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427] ' and Ligand = 'BDBM585796'
TargetIsoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427] (Homo sapiens (Human))
Nurix Therapeutics

US Patent
LigandPNGBDBM585796(US11530229, Compound 11)
Affinity DataIC50:  1.5nMAssay Description:The ability of candidate compounds to displace a known inhibitor and thereby inhibit Cbl-b activity was measured by monitoring the interaction of Cbl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427] (Homo sapiens (Human))
Nurix Therapeutics

US Patent
LigandPNGBDBM585796(US11530229, Compound 11)
Affinity DataIC50:  1.5nMAssay Description:The ability of candidate compounds to displace a known inhibitor and thereby inhibit Cbl-b activity was measured by monitoring the interaction of Cbl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427] (Homo sapiens (Human))
Nurix Therapeutics

US Patent
LigandPNGBDBM585796(US11530229, Compound 11)
Affinity DataIC50:  3nMAssay Description:The ability of candidate compounds to displace a known inhibitor and thereby inhibit Cbl-b activity was measured by monitoring the interaction of Cbl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent