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Found 4 Enz. Inhib. hit(s) with Target = 'Ketohexokinase' and Ligand = 'BDBM494884'
TargetKetohexokinase(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM494884(US10988463, Example 50 | [(1R,5S,6R)-3-{5-cyano-4-...)
Affinity DataIC50:  1.5nMAssay Description:Assay B, using 10-fold less enzyme and measuring absorbance for 3 hours to obtain IC50 values below the 10 nM lower limit of Assay A. Compounds were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKetohexokinase(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM494884(US10988463, Example 50 | [(1R,5S,6R)-3-{5-cyano-4-...)
Affinity DataIC50:  2.60nMAssay Description:Assay C, was performed at high fructose and ATP concentrations, conditions that would be more consistent with physiological concentrations of the nat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKetohexokinase(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM494884(US10988463, Example 50 | [(1R,5S,6R)-3-{5-cyano-4-...)
Affinity DataIC50:  4.40nMAssay Description:Assay A, a 384-well format on a Corning 3653 assay plate is used, and monitored by UV-vis spectroscopy in continuous mode at rt. Compounds were prepa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKetohexokinase(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM494884(US10988463, Example 50 | [(1R,5S,6R)-3-{5-cyano-4-...)
Affinity DataIC50:  4.40nMAssay Description:Assay A, a 384-well format on a Corning 3653 assay plate is used, and monitored by UV-vis spectroscopy in continuous mode at rt. Compounds were prepa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent