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Found 4 Enz. Inhib. hit(s) with Target = 'Lysosomal acid glucosylceramidase' and Ligand = 'BDBM18361'
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Hokuriku University

LigandPNGBDBM18361((2R,3S,4R,5R,6R)-2-butyl-6-(hydroxymethyl)piperidi...)
Affinity DataKi:  1.10E+5nM ΔG°:  -23.5kJ/mole IC50:  1.00E+5nMpH: 5.5 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent 4-MU from the substrate. The fluorescence was measured (excitation 362 nm, emission 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Hokuriku University

LigandPNGBDBM18361((2R,3S,4R,5R,6R)-2-butyl-6-(hydroxymethyl)piperidi...)
Affinity DataIC50:  7.00E+4nMAssay Description:Inhibition of human beta-glucocerebrosidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Hokuriku University

LigandPNGBDBM18361((2R,3S,4R,5R,6R)-2-butyl-6-(hydroxymethyl)piperidi...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of human recombinant beta-glucocerebrosidase preincubated for 10 mins before 4-methylumbelliferyl-betaD-glucopyranoside addition measured ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Bos taurus)
University Of Toyama

Curated by ChEMBL
LigandPNGBDBM18361((2R,3S,4R,5R,6R)-2-butyl-6-(hydroxymethyl)piperidi...)
Affinity DataIC50:  1.20E+5nMAssay Description:Inhibition of bovine liver beta-glucosidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed