Found 5 Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 2' and Ligand = 'BDBM50194618'
Affinity DataKi: 372nMAssay Description:Displacement of [3H]-JNJ46281222 from human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes after 60 mins by microbeta counting a...More data for this Ligand-Target Pair
Affinity DataKd: 600nMAssay Description:Binding affinity to human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataEC50: 231nMAssay Description:The compounds described herein have been shown to be positive allosteric modulators of the mGluR2 receptor using a [35S]-GTPγS binding assay as ...More data for this Ligand-Target Pair
Affinity DataEC50: 562nMAssay Description:Positive allosteric modulation of human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes assessed as increase in glutamate-induced...More data for this Ligand-Target Pair
Affinity DataEC50: 195nMAssay Description:Positive allosteric modulation of human mGlu2 receptor expressed in CHO cell membranes assessed as potentiation of glutamate-induced effect incubated...More data for this Ligand-Target Pair