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Found 3 Enz. Inhib. hit(s) with Target = 'Mineralocorticoid receptor' and Ligand = 'BDBM121428'
TargetMineralocorticoid receptor(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM121428(US8722709, 32)
Affinity DataIC50:  11nMpH: 7.4Assay Description:The MR competitive binding assay is based on the binding and displacement of a TAMRA-labeled Dexamethasone probe with fluorescence polarization (FP) ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMineralocorticoid receptor(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM121428(US8722709, 32)
Affinity DataIC50:  11nMAssay Description:Displacement of TAMRA-labeled dexamethasone from full-length human mineralocorticoid receptor expressed in baculovirus infected insect cells after 60...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMineralocorticoid receptor(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM121428(US8722709, 32)
Affinity DataIC50:  43nMAssay Description:Antagonist activity at Gal4-fused human MR LBD expressed in HEK293T cells assessed as inhibition of aldosterone-induced transactivation activity afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed