Found 5 Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase 7' and Ligand = 'BDBM50605511' TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer
Curated by ChEMBL
Newcastle University Centre For Cancer
Curated by ChEMBL
Affinity DataIC50: 77nMAssay Description:Inhibition of ERK5 (1 to 492 residues) in HEK293 cells assessed as paradoxical activation of ERK5 transcriptional activity incubated for 20 hrs by du...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer
Curated by ChEMBL
Newcastle University Centre For Cancer
Curated by ChEMBL
Affinity DataIC50: 79nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer
Curated by ChEMBL
Newcastle University Centre For Cancer
Curated by ChEMBL
Affinity DataIC50: 141nMAssay Description:Inhibition of ERK5 phosphorylation in human HeLa cells incubated for 1 hr by Western blot densitometry analysisMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer
Curated by ChEMBL
Newcastle University Centre For Cancer
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of full-length ERK5 in HEK293 cells assessed as paradoxical activation of ERK5 transcriptional activity incubated for 20 hrs by dual lucif...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer
Curated by ChEMBL
Newcastle University Centre For Cancer
Curated by ChEMBL
Affinity DataKd: 180nMAssay Description:Binding affinity to wild-type human partial length MAPK7 (M1 to A409 residues) expressed in bacterial expression system by Kinomescan assayMore data for this Ligand-Target Pair
