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Found 11 Enz. Inhib. hit(s) with Target = 'Mu-type opioid receptor' and Ligand = 'BDBM50045767'
TargetMu-type opioid receptor(GUINEA PIG)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50045767((+)-N-phenethyl trans-3(R),4(R)-dimethyl-4-(3-hydr...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity was determined against Mu opioid receptor using [3H]-Naltrexone as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50045767((+)-N-phenethyl trans-3(R),4(R)-dimethyl-4-(3-hydr...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity against Opioid receptor mu 1 using [3H]-Naloxone as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50045767((+)-N-phenethyl trans-3(R),4(R)-dimethyl-4-(3-hydr...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity towards mu opioid receptor by displacement of [3H]-NAL from rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50045767((+)-N-phenethyl trans-3(R),4(R)-dimethyl-4-(3-hydr...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [3H]diprenorphine from human cloned mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50045767((+)-N-phenethyl trans-3(R),4(R)-dimethyl-4-(3-hydr...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [3H]diprenorphine from human cloned mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50045767((+)-N-phenethyl trans-3(R),4(R)-dimethyl-4-(3-hydr...)
Affinity DataKi:  1.90nMAssay Description:Displacement of [3H]diprenorphine from human cloned mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50045767((+)-N-phenethyl trans-3(R),4(R)-dimethyl-4-(3-hydr...)
Affinity DataKi:  1.90nMAssay Description:Inhibition of binding of the non-selective opioid antagonist, [3H]diprenorphine, to cloned human mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50045767((+)-N-phenethyl trans-3(R),4(R)-dimethyl-4-(3-hydr...)
Affinity DataIC50:  1.10nMAssay Description:Antagonist activity assessed as inhibition of loperamide-stimulated [35S]GTPgammaS binding to human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50045767((+)-N-phenethyl trans-3(R),4(R)-dimethyl-4-(3-hydr...)
Affinity DataIC50:  1.10nMAssay Description:Antagonist activity against human cloned mu opioid receptor expressed in CHO cells assessed as inhibition of loperamide-stimulated [35S]GTP-gamma-S b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50045767((+)-N-phenethyl trans-3(R),4(R)-dimethyl-4-(3-hydr...)
Affinity DataIC50:  2nMAssay Description:Concentration required to inhibit agonist (loperamide) stimulated [35S]GTP-gamma-S, binding to membranes containingthe cloned human mu opioid recepto...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50045767((+)-N-phenethyl trans-3(R),4(R)-dimethyl-4-(3-hydr...)
Affinity DataIC50:  2nMAssay Description:Inhibition of loperamide-stimulated [35S]GTPgammaS binding to membranes containing mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed