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Found 6 Enz. Inhib. hit(s) with Target = 'Myeloperoxidase' and Ligand = 'BDBM92469'
TargetMyeloperoxidase(Homo sapiens (Human))
Astrazeneca R&D

LigandPNGBDBM92469(2-Thioxanthine, TX4)
Affinity DataIC50:  200nMpH: 7.4 T: 2°CAssay Description:The chlorination activity of MPO was determined by measuring the production of hypocholorous acid. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Astrazeneca R&D

LigandPNGBDBM92469(2-Thioxanthine, TX4)
Affinity DataIC50:  279nMAssay Description:Inhibition of MPO (unknown origin) measured after 15 mins in presence of H2O2 by chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Astrazeneca R&D

LigandPNGBDBM92469(2-Thioxanthine, TX4)
Affinity DataIC50:  279nMAssay Description:Inhibition of MPO (unknown origin) measured after 15 mins in presence of H2O2 by chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Astrazeneca R&D

LigandPNGBDBM92469(2-Thioxanthine, TX4)
Affinity DataIC50:  2.90E+4nMAssay Description:Inhibition of MPO in human HL-60 cells measured after 15 mins in presence of H2O2 by chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMyeloperoxidase(Mus musculus)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM92469(2-Thioxanthine, TX4)
Affinity DataIC50:  3.25E+4nMAssay Description:Inhibition of PMA-induced MPO in mouse Neutrophil incubated for 3 mins by luminometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Astrazeneca R&D

LigandPNGBDBM92469(2-Thioxanthine, TX4)
Affinity DataKd:  6.31E+4nMAssay Description:Displacement of benzhydroxamic acid from native state MPO (unknown origin) by 1D NMR reporter assayMore data for this Ligand-Target Pair
In DepthDetails PubMed