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Found 5 Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform' and Ligand = 'BDBM50274638'
LigandPNGBDBM50274638(CHEMBL4126156 | US10858355, Example 4)
Affinity DataIC50:  0.631nMAssay Description:The activity of recombinant human PI3Kγ (aa144-1102)-6His was determined by measuring the ADP level after phosphorylation of DiC8-PIP2 using a c...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50274638(CHEMBL4126156 | US10858355, Example 4)
Affinity DataIC50:  0.794nMAssay Description:The activity of recombinant human PI3Kγ (aa144-1102)-6His was determined by measuring the ADP level after phosphorylation of DiC8-PIP2 using a c...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50274638(CHEMBL4126156 | US10858355, Example 4)
Affinity DataIC50:  0.794nMAssay Description:Inhibition of recombinant human PI3Kgamma assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50274638(CHEMBL4126156 | US10858355, Example 4)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of PI3Kgamma in C5a-stimulated mouse RAW 264 cells assessed as inhibition of AKT phosphorylation at Ser473 residue Pretreated for 15 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50274638(CHEMBL4126156 | US10858355, Example 4)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of PI3Kgamma in mouse RAW264 cells assessed as reduction in Akt phosphorylation at Ser473 residue preincubated for 15 mins followed by C5a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed