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Found 3 Enz. Inhib. hit(s) with Target = 'Polycomb protein EED' and Ligand = 'BDBM291911'
TargetPolycomb protein EED(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM291911(8-(2-ethoxy-4-methylpyrimidin-5-yl)-N-((5-fluoro-2...)
Affinity DataIC50:  3.90nMAssay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPolycomb protein EED(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM291911(8-(2-ethoxy-4-methylpyrimidin-5-yl)-N-((5-fluoro-2...)
Affinity DataIC50:  5nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPolycomb protein EED(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM291911(8-(2-ethoxy-4-methylpyrimidin-5-yl)-N-((5-fluoro-2...)
Affinity DataIC50:  6.10nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent