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Found 9 Enz. Inhib. hit(s) with Target = 'Prolyl endopeptidase' and Ligand = 'BDBM50312223'
TargetProlyl endopeptidase(Sus scrofa)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312223((2R,5S,7R)-1-Aza-7-benzyloxycarbonylamino-8-oxo-4-...)
Affinity DataIC50:  200nMAssay Description:Inhibition of poricne POP in cell lysates incubated for 60 mins using Z-Gly-Pro-AMC as a substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))TBA
LigandPNGBDBM50312223((2R,5S,7R)-1-Aza-7-benzyloxycarbonylamino-8-oxo-4-...)
Affinity DataIC50:  200nMAssay Description:Inhibition of POP (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProlyl endopeptidase(Homo sapiens (Human))TBA
LigandPNGBDBM50312223((2R,5S,7R)-1-Aza-7-benzyloxycarbonylamino-8-oxo-4-...)
Affinity DataIC50:  200nMAssay Description:Inhibition of prolyl oligopeptidase in human LNZ308 cell extracts assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))TBA
LigandPNGBDBM50312223((2R,5S,7R)-1-Aza-7-benzyloxycarbonylamino-8-oxo-4-...)
Affinity DataIC50:  500nMAssay Description:Inhibition of prolyl oligopeptidase in human LN229 cell extracts assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))TBA
LigandPNGBDBM50312223((2R,5S,7R)-1-Aza-7-benzyloxycarbonylamino-8-oxo-4-...)
Affinity DataIC50:  700nMAssay Description:Inhibition of prolyl oligopeptidase in human HCEC cell extracts assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))TBA
LigandPNGBDBM50312223((2R,5S,7R)-1-Aza-7-benzyloxycarbonylamino-8-oxo-4-...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of prolyl oligopeptidase in intact human HCEC cells assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))TBA
LigandPNGBDBM50312223((2R,5S,7R)-1-Aza-7-benzyloxycarbonylamino-8-oxo-4-...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of prolyl oligopeptidase in intact human LN229 cells assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))TBA
LigandPNGBDBM50312223((2R,5S,7R)-1-Aza-7-benzyloxycarbonylamino-8-oxo-4-...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of POP (unknown origin) in living cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))TBA
LigandPNGBDBM50312223((2R,5S,7R)-1-Aza-7-benzyloxycarbonylamino-8-oxo-4-...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of prolyl oligopeptidase in intact human LNZ308 cells assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed