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Found 2 Enz. Inhib. hit(s) with Target = 'Protein-serine O-palmitoleoyltransferase porcupine' and Ligand = 'BDBM374948'
TargetProtein-serine O-palmitoleoyltransferase porcupine(Mus musculus)
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM374948(N-(5-(4-acetylpiperazin-1-yl)pyridin-2-yl)-2-(2',3...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of PORCN in mouse Leydig cells overexpressing Wnt3A co-cultured with TM3 cells transfected with Wnt-luciferase gene after 24 hrs by lumine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-serine O-palmitoleoyltransferase porcupine(Mus musculus)
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM374948(N-(5-(4-acetylpiperazin-1-yl)pyridin-2-yl)-2-(2',3...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of PORCN in mouse Leydig cells overexpressing Wnt3A co-cultured with TM3 cells transfected with Wnt-luciferase gene after 24 hrs by lumine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed