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Found 3 Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase B-raf [V600E]' and Ligand = 'BDBM77772'
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM77772(US10245267, Example 232 | US10709712, Example 232 ...)
Affinity DataIC50:  0.800nMpH: 7.5 T: 2°CAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2x final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM77772(US10245267, Example 232 | US10709712, Example 232 ...)
Affinity DataIC50:  0.800nMAssay Description:C-Raf TR refers to a truncated C-Raf protein, a Δ1-324 deletion mutant.C-Raf FL refers to the full-length C-Raf protein.Full length MEK1 with an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM77772(US10245267, Example 232 | US10709712, Example 232 ...)
Affinity DataIC50:  0.800nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent