Found 5 Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase PAK 4' and Ligand = 'BDBM101618' TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Shanghai Chempartner
Curated by ChEMBL
Shanghai Chempartner
Curated by ChEMBL
Affinity DataKi: 15nMAssay Description:Inhibition of N-terminal His6-tagged human recombinant PAK4 (300 to 591 amino acids) using peptide-7 substrate by pyruvate kinase and lactate dehydro...More data for this Ligand-Target Pair
3D Structure (crystal)TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Shanghai Chempartner
Curated by ChEMBL
Shanghai Chempartner
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human PAK4 expressed in TR-293-KDG cells assessed as inhibition of GEFH1 phosphorylation at S180 using GEFH1 as substrate incubated for...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Shanghai Chempartner
Curated by ChEMBL
Shanghai Chempartner
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human PAK4 kinase domain (300 to 591) using peptide 7 as substrate by pyruvate kinase/lactate dehydr...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Shanghai Chempartner
Curated by ChEMBL
Shanghai Chempartner
Curated by ChEMBL
Affinity DataIC50: 38nMAssay Description:Inhibition of human PAK4 assessed as enzymatic activity incubated for 20 mins by filter binding methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Shanghai Chempartner
Curated by ChEMBL
Shanghai Chempartner
Curated by ChEMBL
Affinity DataKd: 2.70nMAssay Description:Binding affinity to human PAK4 (300 to 591 residues) assessed as dissociation constant by isothermal calorimetric analysisMore data for this Ligand-Target Pair
