Compile Data Set for Download or QSAR
maximum 50k data
Found 4 Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase mTOR' and Ligand = 'BDBM50341040'
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50341040(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-N-(1H-pyra...)
Affinity DataIC50:  23nMAssay Description:Inhibition of mTOR by LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50341040(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-N-(1H-pyra...)
Affinity DataIC50:  27nMAssay Description:Inhibition of mTOR assessed as inhibition of phosphorylation of 4EBP1 by Lantha-Screen enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50341040(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-N-(1H-pyra...)
Affinity DataIC50:  55nMAssay Description:Inhibition of mTOR in human U-87 cells assessed as inhibition of phosphorylation of AKT at S473More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50341040(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-N-(1H-pyra...)
Affinity DataIC50:  390nMAssay Description:Inhibition of mTOR in human U-87 cells assessed as inhibition of phosphorylation of 4EBP1 at T37/46More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed