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Found 7 Enz. Inhib. hit(s) with Target = 'Serine-protein kinase ATM' and Ligand = 'BDBM50059640'
TargetSerine-protein kinase ATM(Homo sapiens (Human))TBA
LigandPNGBDBM50059640(CHEMBL2140173)
Affinity DataKi:  2nMAssay Description:Ability to inhibit U-46,619-induced contraction of isolated strips of rabbit thoracic aorta, which is the measure of thromboxane receptor antagonismMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))TBA
LigandPNGBDBM50059640(CHEMBL2140173)
Affinity DataIC50:  6nMAssay Description:Inhibition of ATM kinase in human glioma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))TBA
LigandPNGBDBM50059640(CHEMBL2140173)
Affinity DataIC50:  6nMAssay Description:Inhibition of ATM (unknown origin) by biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))TBA
LigandPNGBDBM50059640(CHEMBL2140173)
Affinity DataIC50:  20nMAssay Description:Inhibition of recombinant full-length human FLAG-tagged ATM assessed as reduction in p53 S15 phosphorylation incubated for 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))TBA
LigandPNGBDBM50059640(CHEMBL2140173)
Affinity DataIC50:  60nMAssay Description:Competitive inhibition of ATM (unknown origin) measured by ATP-competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))TBA
LigandPNGBDBM50059640(CHEMBL2140173)
Affinity DataIC50:  260nMAssay Description:Inhibition of ATM in human MCF7 cells assessed as reduction in etoposide-stimulated KAP1 phosphorylation incubated for 1 hr by ICW assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))TBA
LigandPNGBDBM50059640(CHEMBL2140173)
Affinity DataIC50:  260nMAssay Description:Inhibition of rat neutrophil 5- Lipoxygenase (5-LO)More data for this Ligand-Target Pair
In DepthDetails PubMed