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Found 6 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase BTK' and Ligand = 'BDBM202197'
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM202197(US9233983, P-12)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of recombinant human full length BTK preincubated for 10 mins followed by Tk-biotin peptide substrate addition after 90 mins by TR-FRET as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM202197(US9233983, P-12)
Affinity DataIC50:  22nMAssay Description:The inhibition assays were performed using the generic tyrosine kinase assay kit from C is Bio (HTRF KinEASE-TK #62TK0PEB). The assay is based on t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Mus musculus)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM202197(US9233983, P-12)
Affinity DataIC50:  42nMAssay Description:Inhibition of C57BL/6J mouse BTK assessed as decrease in anti-mouse IgM antibody stimulated BCR mediated CD69 upregulation preincubated for 30 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM202197(US9233983, P-12)
Affinity DataIC50:  261nMAssay Description:Inhibition of human BTK assessed as decrease in anti-mouse IgD antibody stimulated BCR mediated CD69 upregulation in whole blood preincubated for 1 h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Mus musculus)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM202197(US9233983, P-12)
Affinity DataIC50:  364nMAssay Description:Inhibition of mouse BTK assessed as decrease in anti-mouse IgD antibody stimulated BCR mediated CD69 upregulation in whole blood preincubated for 1 h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Mus musculus)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM202197(US9233983, P-12)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of mouse BTK assessed as decrease in anti-CD3epsilon antibody stimulated TCR mediated CD69 upregulation in whole blood preincubated for 1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed