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Found 2 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK2' and Ligand = 'BDBM50303062'
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50303062(3-(6-(pyridin-2-ylmethylamino)pyrimidin-4-yl)pyraz...)
Affinity DataIC50:  22nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50303062(3-(6-(pyridin-2-ylmethylamino)pyrimidin-4-yl)pyraz...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of JAK2-mediated STAT5 phosphorylation in GMCSF-stimulated human TF1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed