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Found 3 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK2' and Ligand = 'BDBM50526468'
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50526468(CHEMBL4442778)
Affinity DataIC50:  12nMAssay Description:Inhibition of recombinant human GST-tagged JAK2 catalytic domain (809 to 1153+9 residues) expressed in baculovirus expression system using TK-biotin ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Rattus norvegicus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50526468(CHEMBL4442778)
Affinity DataIC50:  570nMAssay Description:Inhibition of JAK2 in Lewis rat T cells assessed as reduction in ConA/CD3/CD28-induced cell proliferation measured after 72 hrs by alamar blue staini...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Rattus norvegicus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50526468(CHEMBL4442778)
Affinity DataIC50:  630nMAssay Description:Inhibition of JAK2 in Lewis rat T cells assessed as reduction in IL-2-induced cell proliferation measured after 72 hrs by alamar blue staining based ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed