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Found 3 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM50396071'
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50396071(CHEMBL2170582 | US10828301, Compound R921303)
Affinity DataKi:  1.80nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50396071(CHEMBL2170582 | US10828301, Compound R921303)
Affinity DataIC50:  0.450nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50396071(CHEMBL2170582 | US10828301, Compound R921303)
Affinity DataEC50:  27nMAssay Description:Inhibition of SYK in cultured human mesangial cells assessed as reduction in tryptase releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed