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Found 3 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM620222'
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Calithera Biosciences

US Patent
LigandPNGBDBM620222(BDBM50204292 | US20230295171, Example 82)
Affinity DataIC50:  0.631nMAssay Description:YK protein is prepared from cDNA encoding human spleen tyrosine kinase and is expressed in insect cells using a baculovirus expression vector. The cD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Calithera Biosciences

US Patent
LigandPNGBDBM620222(BDBM50204292 | US20230295171, Example 82)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of human C-terminal 6His-tagged SYK (356 to 635 residues) expressed in Sf9 insect cells using 5-carboxyfluorescein(FAM)-EEPLYWSFPAKKK-NH2 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Calithera Biosciences

US Patent
LigandPNGBDBM620222(BDBM50204292 | US20230295171, Example 82)
Affinity DataEC50:  4nMAssay Description:Inhibition of SYK in TgM-stimulated human Ramos cells expressing RA1/GFP-tagged BLNK assessed as reduction in RA1/GFP-tagged BLNK phosphorylation pre...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed