Affinity DataIC50: 0.100nMAssay Description:Tested for inhibition against purified catalytic subunit of protein phosphatase-1 from rabbit skeletal muscleMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Tested for inhibition against purified catalytic subunit of protein phosphatase-1 from rabbit skeletal muscleMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
Affinity DataIC50: 0.420nMAssay Description:Observed inhibition activity against protein phosphatase 1 (PP1)More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibitory concentration against Protein phosphatase 1 was determined; 0.5-1.0More data for this Ligand-Target Pair
Affinity DataIC50: 0.670nMAssay Description:Observed inhibition activity of the compounds against protein phosphatases 1 (PP1)More data for this Ligand-Target Pair
Affinity DataIC50: <1nMAssay Description:Inhibition of PTPN1 (unknown origin) by Mobility shift assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of PTPN1 (unknown origin) by Mobility shift assayMore data for this Ligand-Target Pair
Affinity DataIC50: <1nMAssay Description:Inhibition of PTPN1 (unknown origin) by Mobility shift assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of PTPN1 (unknown origin) by Mobility shift assayMore data for this Ligand-Target Pair
Affinity DataIC50: <1nMAssay Description:Tested for inhibition against purified catalytic subunit of protein phosphatase-1 from rabbit skeletal muscleMore data for this Ligand-Target Pair
Affinity DataIC50: <1nMAssay Description:Inhibition of PTPN1 (unknown origin) by Mobility shift assayMore data for this Ligand-Target Pair
Affinity DataIC50: <1nMAssay Description:Inhibition of PTPN1 (unknown origin) by Mobility shift assayMore data for this Ligand-Target Pair
Affinity DataIC50: <1nMAssay Description:Inhibition of PTPN1 (unknown origin) by Mobility shift assayMore data for this Ligand-Target Pair
Affinity DataIC50: <1nMAssay Description:Inhibition of PTPN1 (unknown origin) by Mobility shift assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of PTPN1 (unknown origin) by Mobility shift assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Observed inhibition activity of the compounds against protein phosphatases 1 (PP1)More data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Observed inhibition activity against protein phosphatase 1 (PP1)More data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Observed inhibition activity of the compounds against protein phosphatases 1 (PP1)More data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human GST-tagged PTP1B expressed in Escherichia coli using pNPP as substrate by spectroscopic analysisMore data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
Ligand Info
Affinity DataIC50: 1.5nMAssay Description:Observed inhibition activity of the compounds against protein phosphatases 1 (PP1)More data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of PTP1B (unknown origin) using pNPP substrate measured after 3 mins by colorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
Ligand Info
Affinity DataIC50: 2.40nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of flag-tagged PTP1B (1 to 321 residues) (unknown origin) expressed in bacterial expression system by UV/Vis spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition activity against protein phosphatase 1 (PP1), activity taken from literatureMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:The in vitro enzyme inhibitory activity was evaluated by using the pNPP assay. Para-nitrophenylphosphate (pNPP) and test compounds were added to assa...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) was determined in fluorescein diphosphate (FDP) assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.40nMAssay Description:Tested for inhibition against purified catalytic subunit of protein phosphatase-1 from rabbit skeletal muscleMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:The in vitro enzyme inhibitory activity was evaluated by using the pNPP assay. Para-nitrophenylphosphate (pNPP) and test compounds were added to assa...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:The in vitro enzyme inhibitory activity was evaluated by using the pNPP assay. Para-nitrophenylphosphate (pNPP) and test compounds were added to assa...More data for this Ligand-Target Pair
Affinity DataIC50: 4.5nMAssay Description:Inhibition of human recombinant PTP1BMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of human PTP1B (1 to 298 residues) expressed in Escherichia coli using FDP as substrate by microplate readerMore data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
Ligand Info
Affinity DataIC50: 5nMAssay Description:Inhibition of PTP1B (unknown origin) using pNPP as substrateMore data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
Ligand Info
Affinity DataIC50: 5nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of human FLAG-tagged PTP1B catalytic domain (1 to 298) expressed in Escherichia coli using fluorescein diphosphate as substrate by fluores...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of flag-tagged PTP1B (1 to 321 residues) (unknown origin) expressed in bacterial expression system by UV/Vis spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) was determined in fluorescein diphosphate (FDP) assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of PTP1B assessed as para-nitrophenyl phosphate catalyzed hydrolysis of para-nitrophenol by p-NPP assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) was determined in fluorescein diphosphate (FDP) assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:The in vitro enzyme inhibitory activity was evaluated by using the pNPP assay. Para-nitrophenylphosphate (pNPP) and test compounds were added to assa...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:The in vitro enzyme inhibitory activity was evaluated by using the pNPP assay. Para-nitrophenylphosphate (pNPP) and test compounds were added to assa...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of human PTP1B (1 to 321 residues) expressed in Escherichia coli using FDP as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of human PTP1B (1 to 321 residues) expressed in Escherichia coli using FDP as substrateMore data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
Ligand Info
Affinity DataIC50: 6nMAssay Description:Inhibition of human PTP1B (1 to 321 residues) expressed in Escherichia coli using FDP as substrateMore data for this Ligand-Target Pair