Compile Data Set for Download or QSAR
maximum 50k data
Found 4431 of ic50 for UniProtKB: P18031
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50061067(15-(3-Guanidino-propyl)-8-isobutyl-18-((1E,3E)-6-m...)
Affinity DataIC50:  0.100nMAssay Description:Tested for inhibition against purified catalytic subunit of protein phosphatase-1 from rabbit skeletal muscleMore data for this Ligand-Target Pair
In DepthDetails Article
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50110681(CHEMBL430266 | Calyculin-A)
Affinity DataIC50:  0.300nMAssay Description:Tested for inhibition against purified catalytic subunit of protein phosphatase-1 from rabbit skeletal muscleMore data for this Ligand-Target Pair
In DepthDetails Article
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50061066((5R,6S,9S,12S,13S,16R)-2-Eth-(Z)-ylidene-9-(3-guan...)
Affinity DataIC50:  0.420nMAssay Description:Observed inhibition activity against protein phosphatase 1 (PP1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50110681(CHEMBL430266 | Calyculin-A)
Affinity DataIC50:  0.5nMAssay Description:Inhibitory concentration against Protein phosphatase 1 was determined; 0.5-1.0More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50366883(TAUTOMYCIN)
Affinity DataIC50:  0.670nMAssay Description:Observed inhibition activity of the compounds against protein phosphatases 1 (PP1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50212842(Motuporin)
Affinity DataIC50: <1nMAssay Description:Tested for inhibition against purified catalytic subunit of protein phosphatase-1 from rabbit skeletal muscleMore data for this Ligand-Target Pair
In DepthDetails Article
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50579994(CHEMBL5070507)
Affinity DataIC50:  1nMAssay Description:Inhibition of PTPN1 (unknown origin) by Mobility shift assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50580005(CHEMBL5093253)
Affinity DataIC50: <1nMAssay Description:Inhibition of PTPN1 (unknown origin) by Mobility shift assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50580003(CHEMBL5080612)
Affinity DataIC50: <1nMAssay Description:Inhibition of PTPN1 (unknown origin) by Mobility shift assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50580002(CHEMBL5084380)
Affinity DataIC50: <1nMAssay Description:Inhibition of PTPN1 (unknown origin) by Mobility shift assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50580000(CHEMBL5076419)
Affinity DataIC50:  1nMAssay Description:Inhibition of PTPN1 (unknown origin) by Mobility shift assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50579999(CHEMBL5075269)
Affinity DataIC50: <1nMAssay Description:Inhibition of PTPN1 (unknown origin) by Mobility shift assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50579995(CHEMBL5085502)
Affinity DataIC50: <1nMAssay Description:Inhibition of PTPN1 (unknown origin) by Mobility shift assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50579996(CHEMBL5092308)
Affinity DataIC50: <1nMAssay Description:Inhibition of PTPN1 (unknown origin) by Mobility shift assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50579997(CHEMBL5085615)
Affinity DataIC50:  1nMAssay Description:Inhibition of PTPN1 (unknown origin) by Mobility shift assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50110681(CHEMBL430266 | Calyculin-A)
Affinity DataIC50:  1.20nMAssay Description:Observed inhibition activity of the compounds against protein phosphatases 1 (PP1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50110676(CHEMBL280487 | okadaic acid)
Affinity DataIC50:  1.20nMAssay Description:Observed inhibition activity against protein phosphatase 1 (PP1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50061067(15-(3-Guanidino-propyl)-8-isobutyl-18-((1E,3E)-6-m...)
Affinity DataIC50:  1.20nMAssay Description:Observed inhibition activity of the compounds against protein phosphatases 1 (PP1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50611797(CHEMBL5270520)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human GST-tagged PTP1B expressed in Escherichia coli using pNPP as substrate by spectroscopic analysisMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50061069(CHEMBL384277 | Calyculin C)
Affinity DataIC50:  1.5nMAssay Description:Observed inhibition activity of the compounds against protein phosphatases 1 (PP1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50202437(CHEMBL502013)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50069691(Xanthoangelol | Xanthoangerol)
Affinity DataIC50:  2nMAssay Description:Inhibition of PTP1B (unknown origin) using pNPP substrate measured after 3 mins by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50610516(CHEMBL5287377)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50131550((3S)-3-{[(1S)-1-carbamoyl-2-{4-[difluoro(phosphono...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM13599(3-{4-[2-(1H-1,2,3-benzotriazol-1-yl)-3-{4-[difluor...)
Affinity DataIC50:  3nMAssay Description:Inhibition of flag-tagged PTP1B (1 to 321 residues) (unknown origin) expressed in bacterial expression system by UV/Vis spectrophotometryMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50061066((5R,6S,9S,12S,13S,16R)-2-Eth-(Z)-ylidene-9-(3-guan...)
Affinity DataIC50:  3nMAssay Description:Inhibition activity against protein phosphatase 1 (PP1), activity taken from literatureMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM13599(3-{4-[2-(1H-1,2,3-benzotriazol-1-yl)-3-{4-[difluor...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) was determined in fluorescein diphosphate (FDP) assayMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM124215(({7-[2-(1H-1,2,3-benzotriazol-1-yl)-2-({6-bromo-7-...)
Affinity DataIC50:  3nMAssay Description:The in vitro enzyme inhibitory activity was evaluated by using the pNPP assay. Para-nitrophenylphosphate (pNPP) and test compounds were added to assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50110676(CHEMBL280487 | okadaic acid)
Affinity DataIC50:  3.40nMAssay Description:Tested for inhibition against purified catalytic subunit of protein phosphatase-1 from rabbit skeletal muscleMore data for this Ligand-Target Pair
In DepthDetails Article
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM124216(({7-[2-({7-[(aminosulfinyl)difluoromethyl]-6-bromo...)
Affinity DataIC50:  4nMAssay Description:The in vitro enzyme inhibitory activity was evaluated by using the pNPP assay. Para-nitrophenylphosphate (pNPP) and test compounds were added to assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM124221(({2-[2-({7-[(aminosulfinyl)difluoromethyl]-6-bromo...)
Affinity DataIC50:  4nMAssay Description:The in vitro enzyme inhibitory activity was evaluated by using the pNPP assay. Para-nitrophenylphosphate (pNPP) and test compounds were added to assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50104694((R)-4-hydroxy-5-(hydroxymethyl)-3-palmitoylfuran-2...)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of human recombinant PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50612109(CHEMBL5275241)
Affinity DataIC50:  5nMAssay Description:Inhibition of PTP1B (unknown origin) using pNPP as substrateMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50308854(CHEMBL590235 | [7-(4-{1-Benzotriazol-1-yl-2-[4-(di...)
Affinity DataIC50:  5nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50535627(CHEMBL4542052)
Affinity DataIC50:  5nMAssay Description:Inhibition of human FLAG-tagged PTP1B catalytic domain (1 to 298) expressed in Escherichia coli using fluorescein diphosphate as substrate by fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50612104(CHEMBL5290902)
Affinity DataIC50:  5nMAssay Description:Inhibition of human PTP1B (1 to 298 residues) expressed in Escherichia coli using FDP as substrate by microplate readerMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM13604(6-{4-[2-(1H-1,2,3-benzotriazol-1-yl)-3-{4-[difluor...)
Affinity DataIC50:  5nMAssay Description:Inhibition of flag-tagged PTP1B (1 to 321 residues) (unknown origin) expressed in bacterial expression system by UV/Vis spectrophotometryMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50142323(CHEMBL267488 | [(4-{2-Benzotriazol-1-yl-3-[3-bromo...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) was determined in fluorescein diphosphate (FDP) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50362181(({7-[2-(1H-1,2,3-benzotriazol-1-yl)-2-({6-bromo-7-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of PTP1B assessed as para-nitrophenyl phosphate catalyzed hydrolysis of para-nitrophenol by p-NPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50362181(({7-[2-(1H-1,2,3-benzotriazol-1-yl)-2-({6-bromo-7-...)
Affinity DataIC50:  5nMAssay Description:The in vitro enzyme inhibitory activity was evaluated by using the pNPP assay. Para-nitrophenylphosphate (pNPP) and test compounds were added to assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM124220(({2-[2-(1H-1,2,3-benzotriazol-1-yl)-2-({6-bromo-7-...)
Affinity DataIC50:  5nMAssay Description:The in vitro enzyme inhibitory activity was evaluated by using the pNPP assay. Para-nitrophenylphosphate (pNPP) and test compounds were added to assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM13604(6-{4-[2-(1H-1,2,3-benzotriazol-1-yl)-3-{4-[difluor...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) was determined in fluorescein diphosphate (FDP) assayMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50308854(CHEMBL590235 | [7-(4-{1-Benzotriazol-1-yl-2-[4-(di...)
Affinity DataIC50:  5nMAssay Description:Inhibition of PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50142311(CHEMBL266056 | [(4-{2-[4-(Difluoro-phosphono-methy...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human PTP1B (1 to 321 residues) expressed in Escherichia coli using FDP as substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50612064(CHEMBL5285288)
Affinity DataIC50:  6nMAssay Description:Inhibition of human PTP1B (1 to 321 residues) expressed in Escherichia coli using FDP as substrateMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM124217(({7-[2-({7-[(aminosulfinyl)difluoromethyl]-6-bromo...)
Affinity DataIC50:  6nMAssay Description:The in vitro enzyme inhibitory activity was evaluated by using the pNPP assay. Para-nitrophenylphosphate (pNPP) and test compounds were added to assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50142317((2-bromo-4-(3-oxo-2,3-diphenylpropyl)phenyl)difluo...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human PTP1B (1 to 321 residues) expressed in Escherichia coli using FDP as substrateMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50243184({[2-Bromo-4-(40-bromo-30-sulfamoylbiphenyl-4-ylmet...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human PTP1B expressed in Escherichia coli BL21(DE3) cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50142318(CHEMBL428651 | {[2-Chloro-4-(3-oxo-2,3-diphenyl-pr...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human PTP1B (1 to 321 residues) expressed in Escherichia coli using FDP as substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50500147(CHEMBL3746639)
Affinity DataIC50:  7nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Displayed 1 to 50 (of 4431 total ) | Next | Last >>
Jump to: